Role of Src expression and activation in human cancer

By R. Irby, Timothy Yeatman. Oncogene, 2000

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Src family kinases in tumor progression and metastasis (2003, background): “In the absence of mutation, kinase activity may be augmented through displacement of the intramolecular interactions via higher affinity binding between the SH3 and SH2 domains and their cellular ligands and/or through dephosphorylation of the carboxy-terminal regulatory tyrosine, normally phosphory”
Kinase-targeted cancer therapies: progress, challenges and future directions (2018, background): “The product of the human SRC gene, c-Src, is found to be overexpressed and highly activated in a wide variety of human cancers [215].”