microRNAs exhibit high frequency genomic alterations in human cancer.

By Lin Zhang, Jia Huang, N. Yang, J. Greshock, Molly Megraw, Antonis Giannakakis, Shun Liang, Tara L. Naylor, A. Barchetti, M. Ward and 8 more. Proceedings of the National Academy of Sciences of the United States of America, 2006

1,119 citations recorded by the source corpus.

Subfields: Cancer Research, Plant Science

View Paper: https://www.semanticscholar.org/paper/8c9501b5bef568dd7c6fc72a189c35d68b6beb4a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

In Plant Science

Citations in the corpus

MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review (2012, neutral): “…regions of the genome involved in alterations in cancer (Calin et al, 2004), and conﬁrmed by several studies (Calin et al, 2002; Tagawa & Seto, 2005; Zhang et al, 2006); mutations, as the inherited mutations in the primary transcripts of miR-15a and miR-16-1 responsible for reduced expression of…”
MicroRNA-34b and MicroRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth. (2007, background): “Dysregulated miRNA expression may occur via a number of mechanisms, such as gene copy gain or loss (4), germline mutation of precursor miRNA molecules (5), promoter methylation (6), or aberrant miRNA processing due to altered expression of miRNA biogenesis machinery (7).”
The biology of ovarian cancer: new opportunities for translation (2009, background): “DNA copy number abnormalities have also been found in 37% of 283 loci that are known to contain non-coding microRNA”
Micro-RNA profiling in kidney and bladder cancers. (2007, background): “[7] Zhang L, Huang J, Yang N, et al.”
The neuronal microRNA system (2006, background): “One approach taken by cancer investigators has identified the genomic sites in which miRNAs are encoded, and found that a high proportion of genomic loci containing miRNA genes exhibited DNA copy number alterations in common cancer”
MicroRNA expression profiling in prostate cancer. (2007, background): “After this initial finding, more than half of the known miRNAs have been reported to be located in cancer-associated genomic regions and to show copy number alterations in cancer (7, 8 ), and deregulation of several miRNAs, such as miR-143, miR-145, miR-21, BIC/miR-155, and the let-7 family, has be”
Non‐coding RNAs: regulators of disease (2010, background): “MicroRNA loci and individual components of the miRNA biogenesis pathway are frequently lost or amplified in a wide range of cancers [160,161], and there is now widespread evidence that miRNAs that act as differentiation factors (e.”
Therapeutic delivery of miR-26a inhibits cancer cell proliferation and induces tumor-specific apoptosis (2009, positive): “For example, miRNAs are known targets of genomic lesions that frequently activate oncogenes and inactivate tumor suppressors in cancer cells, such as amplification, deletion, and epigenetic silencing (Calin et al., 2004; Lujambio and Esteller, 2007; Zhang et al., 2006).”
Non-coding RNAs in disease: from mechanisms to therapeutics (2023, positive): “Soon after these discoveries, other miRNA-encoding loci were shown to be frequently located in the fragile regions of chromosomes 107,108 and lost or disrupted in various cancer types 53,109,110 .”
MicroRNAs in development and disease. (2011, background): “Indeed, it was found that 37% of miRNA genes are encompassed in genomic regions that are subject to DNA copy abnormalities in OC (705), while 36% exhibit epigenetic silencing (706).”