Long-term behavioral and neuroendocrine adaptations to adverse early experience.

By Charlotte O. Ladd, R. Huot, K. Thrivikraman, C. Nemeroff, Michael Joseph Meaney, P. Plotsky. Progress in Brain Research, 2000

744 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Cellular and Molecular Neuroscience, Social Psychology

View Paper: https://www.semanticscholar.org/paper/8c92e65057330ad8c04b589e4ea443a3d07fdd67

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Behavioral Neuroscience

In Cellular and Molecular Neuroscience

In Social Psychology

Citations in the corpus

Neurobiological and psychiatric consequences of child abuse and neglect. (2010, background): “…rodent and nonhuman primate studies have revealed a number of persistent neurobiological consequences of early-life trauma (e.g., reviewed in Francis, Caldji, Champagne, Plotsky, & Meaney, 1999; Heim & Nemeroff, 2001; Kaufman, Plotsky, Nemeroff, & Charney, 2000; Ladd et al., 2000; Meaney, 2001).”
Regulation of the Hypothalamic‐Pituitary‐Adrenocortical Stress Response (2016, neutral): “Prolonged maternal deprivation or an impoverished maternal environment produce disorganized maternal behavior that results in an overreactive HPA axis in offspring [see (96)].”
Variations in maternal care in the rat as a mediating influence for the effects of environment on development. (2003, neutral): “[1–4]).”
Stress and depression. (2005, positive): “…has been an additional emphasis on the role of early exposure to childhood adversity, trauma, and abuse in promoting abnormalities of HPA axis activity that result in sensitization to the effects of later stressors (e.g., reviewed in Heim & Nemeroff 2001, Kaufman et al. 2000, Ladd et al. 2000).”
The developing brain and neural plasticity: Implications for normality, psychopathology, and resilience. (2015, background): “been devoted to examining the effects that stress and adversity exert on the brain and neuroendocrine and immunological systems (for reviews, see Granger, Dreschel, & Shirtcliff, 2003; Gunnar, 1998; Kaufman, Plotsky, Nemeroff, & Charney, 2000; Kiecolt-Glaser, McGuire, Robles, & Glaser, 2002; Ladd et”
High antenatal maternal anxiety is related to ADHD symptoms, externalizing problems, and anxiety in 8- and 9-year-olds. (2004, background): “Disturbance in HPA axis regulation and brain monoamine levels are associated with several disorders in humans (Herlenius & Lagercrantz, 2001; Herman et al., 2003; Huizink, Mulder, & Buitelaar, 2004; Ladd et al., 2000; Maccari et al., 2003; Weinstock, 2001; Welberg & Seckl, 2001).”
A modern learning theory perspective on the etiology of panic disorder. (2001, background): “In addition, building on the pioneering efforts of Ader and Denenberg, Nemeroff et al. (e.g., Heim & Nemeroff, 1999; Ladd et al., 2000) noted permanent effects on brain function of early stressful experiences (separation) in rat pups.”
The link between childhood trauma and depression: insights from HPA axis studies in humans. (2008, positive): “Findings from animal models provide firm evidence for multiple changes in these circuits that occur as a consequence of early-life stress (e.g., Ladd et al., 2000; Sánchez et al., 2001; Meaney and Szyf, 2005 ).”
Stress and health: psychological, behavioral, and biological determinants. (2005, background): “In contrast to highly nurtured rats, pups separated from their mothers for several hours per day during early life have a highly active hypothalamic-pituitary adrenocortical axis and elevated SNS arousal (Ladd et al. 2000).”
The neurobiology of stress and gastrointestinal disease (2000, background): “…in this central adaptation to pathological stress are an increase in CRF synthesis and secretion, 65 66 67 an increase in the activity and sensitivity of central noradrenergic systems, 31 68–71 and either downregulation or sensitisation of GC receptors and adrenocorticotropic hormone release.”
Environmental Enrichment Reverses the Effects of Maternal Separation on Stress Reactivity (2002, background): “Antidepressant drugs attenuate the effect of MS on HPA responses to stress (Ladd et al., 2000).”
Drug Addiction, Dysregulation of Reward, and Allostasis (2001, background): “Both perinatal and developmental stressors can contribute to the vulnerability of the brain and pituitary stress systems (Caldji et al. 1998; Ladd et al. 2000), and such a vulnerability may impact directly on negative affective states that contribute to reward system allostasis.”
The brain and the stress axis: The neural correlates of cortisol regulation in response to stress (2009, background): “Maternal deprivation, on the other hand, was shown to be associated with decreased glucocorticoid receptor expression in the HC and the frontal cortex, decreased glucocorticoid negative feedback (Ladd et al., 2000), and increased CRH mRNA expression in the PVN, the central nucleus of the AG, the BNS”