Nanosuspensions in drug delivery

By B. Rabinow. Nature reviews. Drug discovery, 2004

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Drug Nanoparticles: Formulating Poorly Water-Soluble Compounds (2008, background): “…is practically insoluble in the blood pool, when dosed, drug nanoparticles will behave very similarly to the other nanoparticulate platforms described above; that is, size and coating can be used to target or avoid the MPS system (MeriskoLiversidge, Liversidge, et al., 2004; Rabinow, 2004).”
The journey of a drug-carrier in the body: an anatomo-physiological perspective. (2012, background): “, pulmonary [19], oral [20]), the most reproducible way to deliver them is usually by peripheral intravenous injection.”
Top-down production of drug nanocrystals: nanosuspension stabilization, miniaturization and transformation into solid products. (2008, background): “Both polymeric stabilizers and surfactant stabilizers can be used for this purpose (Rabinow, 2004).”
Nanosuspension: An approach to enhance solubility of drugs (2011, background): “[5] Nanosuspensions are submicron colloidal dispersions of nanosized drug particles stabilized by surfactants.[6] Nanosuspensions consist of the poorly water-soluble drug without any matrix material suspended in dispersion.”
The potential advantages of nanoparticle drug delivery systems in chemotherapy of tuberculosis. (2005, background): “More details on the application of nanosuspensions in drug delivery can be found in a review on this subject (27).”