Nanosuspension: An approach to enhance solubility of drugs
By V. R. Patel, Y. Agrawal. Journal of Advanced Pharmaceutical Technology & Research, 2011
637 citations recorded by the source corpus.
One of the major problems associated with poorly soluble drugs is very low bioavailability. The problem is even more complex for drugs like itraconazole, simvastatin, and carbamazepine which are poorly soluble in both aqueous and nonaqueous media, belonging to BCS class II as classified by biopharmaceutical classification system. Formulation as nanosuspension is an attractive and promising alternative to solve these problems. Nanosuspension consists of the pure poorly water-soluble drug without any matrix material suspended in dispersion. Preparation of nanosuspension is simple and applicable to all drugs which are water insoluble. A nanosuspension not only solves the problems of poor solubility and bioavailability, but also alters the pharmacokinetics of drug and thus improves drug safety and efficacy. This review article describes the preparation methods, characterization, and applications of the nanosuspension.
Subfields: Analytical Chemistry, Pediatrics, Perinatology and Child Health, Pharmaceutical Science
View Paper: https://www.semanticscholar.org/paper/bbad14f996fd2a4e5b0653d80075180bbf000a86
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In Analytical Chemistry
In Pediatrics, Perinatology and Child Health
In Pharmaceutical Science
Citations in the corpus
- DLS and zeta potential - What they are and what they are not? (2016, background): “Guidelines classifying NP-dispersions with ZP values of ±0– 10mV,±10–20mV and±20–30mV and ˃±30mV as highly unstable, relatively stable, moderately stable and highly stable, respectively are common in drug delivery literature [116].”