Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.

By S. Kim, R. Sprung, Yue Chen, Yingda Xu, H. Ball, Jimin Pei, Tzuling Cheng, Y. Kho, Hao Xiao, Lin Xiao and 4 more. Molecules and Cells, 2006

1,527 citations recorded by the source corpus.

Subfields: Geriatrics and Gerontology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8c50fa295e6406f362f099992e4d69e712c54a9a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Geriatrics and Gerontology

In Molecular Biology

Citations in the corpus

Acetylation Targets the M2 Isoform of Pyruvate Kinase for Degradation through Chaperone-Mediated Autophagy and Promotes Tumor Growth (2011, positive): “Protein acetylation has recently emerged as a broadly used modification in the regulation of a wide range of cellular processes (Choudhary et al., 2009; Kim et al., 2006; Zhao et al., Mol Cell.”
The biological impact of mass-spectrometry-based proteomics (2007, background): “Similar approaches are emerging for the global analysis of other key protein modifications, including acetylatio”
Decoding signalling networks by mass spectrometry-based proteomics (2010, background): “Enrichment of peptides containing acetylated Lys residues revealed a surprisingly large number of acetylation sites on mitochondrial protein”
The First Identification of Lysine Malonylation Substrates and Its Regulatory Enzyme* (2011, methodology): “The protein precipitate was digested by trypsin using a procedure we described previously (8).”
SIRT5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle (2009, positive): “Because mitochondrial CPS1 was found to be acetylated (Kim et al., 2006), SIRT5 could upregulate CPS1 activity via deacetylation.”
SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome (2011, positive): “Global mitochondrial protein acetylation is regulated by the nutritional status of the cell and is sensitive to fasting (Kim et al., 2006), calorie restriction (Schwer et al.”
Mapping protein post-translational modifications with mass spectrometry (2007, background): “A wide range of acetyllysine sites were mapped by enriching acetylated peptides using resin-coupled antibodies to acetyllysin”
Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. (2010, background): “SOD2 was identified in mass spectrometry-based screens for acetylated peptides (Choudhary et al., 2009; Kim et al., 2006, 2010; Schwer et al., 2009).”
Lysine Propionylation and Butyrylation Are Novel Post-translational Modifications in Histones*S (2007, methodology): “A recent proteomics screening showed that acetyllysine is abundant and present in substrates that are affiliated with multiple organelles and have diverse functions (6).”
PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse (2011, background): “This technology has similarly transformed the identiﬁcation of other modiﬁcation types including ubiquitination (11–13), acetylation (14,15) and O-GlcNAcylation (16).”
Mammalian Sir2 Homolog SIRT3 Regulates Global Mitochondrial Lysine Acetylation (2007, background): “One of these GDH acetylation sites (K527) has been reported previously (21).”