A histone H3 lysine 27 demethylase regulates animal posterior development

By F. Lan, P. Bayliss, Johannes Rinn, J. Whetstine, Jordon K. Wang, Shuzhen Chen, Shigeki Iwase, Roman Alpatov, Irina Issaeva, E. Canaani and 3 more. Nature, 2007

798 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8c0305ac7a05310218d7a55c61e8004f40b55e8c

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In Cancer Research

1. Shizuo Akira
2. O. Takeuchi
3. Kenta Nakai
4. Daron M. Standley
5. Wee-Wei Tee
6. P. Voigt
7. D. Reinberg
8. Taro Kawai

In Molecular Biology

1. Shizuo Akira
2. A. Shilatifard
3. O. Takeuchi
4. P. Voigt
5. Wee-Wei Tee
6. D. Reinberg
7. Dirk Schübeler
8. Edwin R. Smith

Citations in the corpus

• Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors. (2008, background): “However, while DNA methylation is considered a stable epigenetic silencer, Polycomb-mediated repression is reversible, as targets such as Hox genes are activated in a cell-type-specific manner (Agger et al., 2007; Bracken et al., 2006; Lan et al., 2007; Lee et al., 2007; Mikkelsen et al., 2007).”
• DNA Demethylation in Zebrafish Involves the Coupling of a Deaminase, a Glycosylase, and Gadd45 (2008, positive): “The relevance of this approach is supported by the common observation that human orthologs effectively complement their zebrafish orthologs in knockdown/ complementation studies (Lan et al., 2007; Rai et al., 2006) and expression of hMbd4 effectively complemented zMbd4 knockdown for phenotypic defec”
• Covalent modifications of histones during development and disease pathogenesis (2007, background): “The reciprocal relationship of H3K4 and H3K27 methylation exemplified by the TrxG and PcG antagonism is further strengthened by the existence of H3K27 demethylases, JMJD3 and the related UTX (refs”
• A double take on bivalent promoters. (2013, background): “Both UTX and JMJD3 rarely localize to bivalent promoters in ES cells but are recruited upon differentiation and are necessary for gene activation (Agger et al. 2007; Lan et al. 2007; Lee et al. 2007; Burgold et al. 2008).”
• The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection (2010, background): “Proteins harboring a Jumonji-C (JmjC) domain, such as Jmjd3, Utx and Uty, are known to act as H3K27 demethylases, catalyzing the conversion of H3K27me3 (trimethylated) to H3K27me1 (monomethylated”