Variation in the safety of induced pluripotent stem cell lines

By Kyoko Miura, Y. Okada, T. Aoi, Aki Okada, Kazutoshi Takahashi, K. Okita, M. Nakagawa, Michiyo Koyanagi, K. Tanabe, M. Ohnuki and 4 more. 2009

913 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology

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Citations in the corpus

Epigenetic memory in induced pluripotent stem cells (2010, background): “When differentiated into neurospheres, iPSC from adult tail-tip fibroblasts retain more teratoma-forming cells than iPSC from embryonic fibroblasts, again indicating heterogeneity based on the tissue of origin 11 .”
Highly efficient reprogramming to pluripotency and directed differentiation of human cells using synthetic modified mRNA (2010, background): “The risk of mutagenesis is not the only safety concern holding back clinical application of induced pluripotency, and it has become increasingly apparent that all iPSCs are not created equal with respect to epigenetic landscape and developmental plasticity (Hu et al., 2010; Miura et al., 2009).”
The tumorigenicity of human embryonic and induced pluripotent stem cells (2011, background): “A study of the tumorigenicity of mouse iPSCs has recently been publishe”
Direct conversion of human fibroblasts to dopaminergic neurons (2011, background): “In theory, the avoidance of reprogramming via a pluripotent state should reduce the risk of tumor formation after intracerebral grafting that is associated with the use of embryonic stem cells and iPS cells (24); thus, hiN cells may provide safer cells for transplantation in future applications.”
Induced pluripotency: history, mechanisms, and applications. (2010, background): “Likewise, an increased propensity of iPSC-derived neural cells to form tumors after transplantation into the brains of immunocompromised mice has been observed (Miura et al. 2009).”
Generation of regionally specified neural progenitors and functional neurons from human embryonic stem cells under defined conditions. (2012, background): “Despite the short culture time prior to transplantation, the grafts showed no signs of tumor formation or necrosis, which are features otherwise commonly associated with transplantation of progenitors derived from pluripotent stem cells (Miura et al., 2009; Roy et al., 2006).”
The promise of induced pluripotent stem cells in research and therapy (2012, background): “Some mouse iPS cells showed lower efficiencies of teratoma formation than mouse ES cells, whereas some human iPS cells showed less propensity to differentiate along haematopoietic, neuroepithelial and neuronal lineages than human ES cell”