Direct conversion of human fibroblasts to dopaminergic neurons
By U. Pfisterer, A. Kirkeby, Olof Torper, J. Wood, J. Nelander, A. Dufour, A. Björklund, O. Lindvall, Johan Jakobsson, M. Parmar. Proceedings of the National Academy of Sciences of the United States of America, 2011
786 citations recorded by the source corpus.
Subfields: Cellular and Molecular Neuroscience, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/7bf25df53f7d3f37b1b8266dc5c4120059e294b7
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In Cellular and Molecular Neuroscience
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Citations in the corpus
- Midbrain-like organoids from human pluripotent stem cells contain functional dopaminergic and neuromelanin producing neurons (2016, background): “…than 20% of neurons within the hMLOs showed rhythmic discharges, with an average frequency of 2.78 Hz (Figures 4H and 4I), and rebound depolarizations resulted in AP generation after short hyperpolarization of neurons (Figure 4J), which are characteristics of mDA neurons (Pfisterer et al., 2011).”
- In vivo direct reprogramming of reactive glial cells into functional neurons after brain injury and in an Alzheimer’s disease model (2013, background): “Many studies have since demonstrated transdifferentiation across different cell lineages, including reprogramming mouse or human fibroblasts directly into neurons (Ambasudhan et al., 2011; Caiazzo et al., 2011; Kim et al., 2011; Ladewig et al., 2012; Liu et al., 2012, 2013; Meng et al., 2012; Pang e”