Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1
By Yue-Ming Li, Min Xu, M. Lai, Qian Huang, J. Castro, J. DiMuzio-Mower, T. Harrison, C. Lellis, A. Nadin, J. G. Neduvelil and 8 more. Nature, 2000
834 citations recorded by the source corpus.
Subfields: Molecular Biology, Pharmacology, Physiology
View Paper: https://www.semanticscholar.org/paper/8bbeacab6dedde266d2e73d6cac93643154e430a
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Citations in the corpus
- Calcium dyshomeostasis and intracellular signalling in alzheimer's disease (2002, background): “Despite the preponderance of evidence that this might be the cas”
- A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity (2001, background): “Several of these inhibitors have been demonstrated to bind presenilins, leading to the hypothesis that presenilins are actual γ-secretase”
- Cell biology of protein misfolding: The examples of Alzheimer's and Parkinson's diseases (2004, background): “The discovery that all presenilins contain two aspartate residues in transmembrane domains 6 and 7 of this putatively eight-spanning transmembrane polypeptide and that these represent the active site of γ-secretase revealed that presenilin functioned as an unprecedented intramembrane aspartyl protea”
- APP processing and synaptic function. (2003, neutral): “…the requirement for -secretase processing of APP on the depressive effect on synaptic transmis- The requirement for BACE and -secretase processing of recombinant APP strongly suggests that A mediatession, we employed a highly potent and selective -secretase inhibitor, L-685,458 (Li et al., 2000).”
- Deciphering the molecular basis of memory failure in Alzheimer's disease. (2004, background): “Function Li et al., 2000; Wolfe et al., 1999).”
- Notch signaling: from the outside in. (2000, background): “All right resenilin-containing complex, wherein g-secretase activity resides (Li et al., 2000b), has been identified.”
- Amyloidogenic processing of the Alzheimer β-amyloid precursor protein depends on lipid rafts (2003, background): “Also the -secretase complex was shown to be raft associated (Li et al., 2000; Wahrle et al., 2002).”