Cell biology of protein misfolding: The examples of Alzheimer's and Parkinson's diseases

By D. Selkoe. Nature Cell Biology, 2004

894 citations recorded by the source corpus.

Subfields: Cell Biology, Neurology, Physiology

View Paper: https://www.semanticscholar.org/paper/55f0f716a355adc7e29593bf650590b1a5a552b5

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Citations in the corpus

Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase (2006, background): “This has led to the discovery of common pathophysiological pathways such as enhanced oxidative stress, protein misfolding and aggregation and dysfunction of the ubiquitin-proteasome syste”
AGGRESCAN: a server for the prediction and evaluation of "hot spots" of aggregation in polypeptides (2007, neutral): “Actually, Tau is an usually highly soluble microtubule-associated protein [28] but in Alzheimer's disease it aggregates into fibres with a tendency to form neurofibrillary tangles.”
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis (2007, background): “…neurodegenera- tion raises the possibility of developing a class of therapeutic interventions that treat a variety of neurological disorders by activating the body’s own defenses against age-related dete- rioration and cell death (Bossy-Wetzel et al, 2004; Forman et al, 2004; Selkoe, 2004).”
Alzheimer’s disease: pathogenesis, diagnostics, and therapeutics (2019, background): “which is soluble and translocates to nuclei for further geneexpression function.(5)”
CSF biomarkers and incipient Alzheimer disease in patients with mild cognitive impairment. (2009, methodology): “A 142 levels were determined using a sandwich ELISA (Innotest -amyloid[1-42]), specifically constructed to measure A containing both the 1st and 42nd amino acids, as previously described.”
The emerging field of lipidomics (2005, background): “A common mechanistic explanation for many of the above disorders is imbalanced protein–protein and protein–lipid interactions, both of which lead to an increased probability of the formation of (intracellular) protein deposit”
Rho kinase, a promising drug target for neurological disorders (2005, background): “In addition, significant correlations in humans have been reported between levels of soluble Aβ42, the formation of small aggregates (oligomers) and the extent of cognitive impairmen”