The Fas Signaling Pathway: More Than a Paradigm

By Harald Wajant. Science, 2002

1,008 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8ba7d35853d95f643bd76286f8c5b9dc41a3d98a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

In Molecular Biology

Citations in the corpus

Targeting Apoptosis Pathways in Cancer Therapy (2005, background): “tivating protein 1 that regulate the FasL gene, because it is a transcriptionally inactive gene.(11)”
Anoikis: an emerging hallmark in health and diseases (2012, background): “Autoactivated caspase-8 then proteolytically activates caspase-3 and -7, culminating in substrate proteolysis and cell death [16,31].”
Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesis. (2008, background): “is classically mediated by binding of death signals (Fas ligands) to death receptors (Fas) on the cell surface leading to aggregation of Fas receptors, caspase-8 and Fas-associated death domain protein into a death-inducing signaling complex in which caspase-8 is proteolytically activated and then r”
Apoptosis and melanoma chemoresistance (2003, background): “This pathway is also regulated at multiple levels as the DISC can also recruit positive and negative regulators of the caspase 8 (Tschopp et al., 1998; Wajant, 2002).”
Anoikis molecular pathways and its role in cancer progression. (2013, background): “Active caspase-8 is then released to the cytoplasm where it cleaves and activates the effectors caspase-3, -6, and -7, culminating in substrate proteolysis and cell death [221,235].”
Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis (2019, background): “The extrinsic pathway is initiated by the tumor necrosis factor (TNF) receptor family interacting with a ligand and then binds with procaspase-8 following ligand-receptor interaction to activation of caspase-3 which leads to execution of apoptosis [54, 55].”
Osteoblast-Osteoclast Communication and Bone Homeostasis (2020, background): “FAS ligand (FASL or CD95L) plays a central role in the physiological regulation of apoptosis of FAS-expressing cells, which is associated with various disease processes, such as tumorigenesis and several auto-immune diseases [31,32].”
Apoptosis: A Review of Programmed Cell Death (2007, background): “The binding of Fas ligand to Fas receptor results in the binding of the adapter protein FADD and the binding of TNF ligand to TNF receptor results in the binding of the adapter protein TRADD with recruitment of FADD and RIP (Hsu et al., 1995; Grimm et al., 1996; Wajant, 2002).”
Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012 (2011, background): “(TNFR1) and TRAIL receptor (TRAILR)1–2, respectively).(28) Alternatively, an extrinsic pro-apoptotic signal can be dispatched by the so-called ‘dependence receptors’, including”