Interleukin-10: new perspectives on an old cytokine

By D. Mosser, Xia Zhang. Immunological Reviews, 2008

1,122 citations recorded by the source corpus.

Summary: Interleukin‐10 (IL‐10) has long been recognized to have potent and broad‐spectrum anti‐inflammatory activity, which has been unequivocally established in various models of infection, inflammation, and even in cancer. However, because of the marginal successes of the initial clinical trials using recombinant IL‐10, some of the interest in this cytokine as an anti‐inflammatory therapeutic has diminished. New work showing IL‐10 production from regulatory T cells and even T‐helper 1 T cells has reinvigorated the field and revealed the power of this cytokine to influence immune responses. Furthermore, new preclinical studies suggest that combination therapies, using antibodies to IL‐10 along with chemotherapy, can be effective in treating bacterial, viral, or neoplastic diseases. Studies to understand IL‐10 gene expression in the various cell types may lead to new therapeutics to enhance or inhibit IL‐10 production. In this review, we summarize what is known about the regulation of IL‐10 gene expression by various immune cells. We speculate on the promise that this cytokine holds to influence immune responses and mitigate immune pathologies.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/a241c035841381572fc7b2eb3648f152eac68804

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Citations in the corpus

Heterogeneity of Microglial Activation in the Innate Immune Response in the Brain (2009, background): “The signaling pathways involved in TGF-βmediated immunosuppression have been extensively reviewed by Li et al. (2006) and for IL-10 by Mosser and Zhang (2008).”
Role of Interleukin 10 Transcriptional Regulation in Inflammation and Autoimmune Disease (2012, background): “N IH -PA Author M anuscript N IH -PA Author M anuscript N IH -PA Author M anuscript IL-10 inducing signaling cascades have been studied less thoroughly in 3 cells than in macrophages and DCs. Stimulation of IL-10 expression can occur through one of three mechanisms: (1) instruction by APCs, (2) indu”
Anti- and Pro-inflammatory Roles of TGF-β, IL-10, and IL-22 In Immunity and Autoimmunity (2009, background): “Importantly, the IL-10 promoter itself has a Stat3 binding site, suggesting a positive feed-back loop for IL-10-Stat3 signaling [30].”
IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses (2011, background): “The main producers of IL-10 include M2 macrophages, B cells and T cell”
Vitamin D: modulator of the immune system. (2010, background): “Furthermore, 1,25(OH)2D3 also modulates DC-derived cytokine and chemokine expression, by inhibiting the production of IL-12 and IL-23 (known as major cytokines driving Th1differentiation and Th17-differentiation respectively), and enhancing the release of IL-10 (a cytokine exerting broad-spectrum an”