Neonatal adaptive immunity comes of age

By B. Adkins, C. Leclerc, S. Marshall‐clarke. Nature reviews. Immunology, 2004

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Macrophages are required for neonatal heart regeneration. (2014, neutral): “Furthermore, within the TCR+ population of the spleen, P1 mice had a significantly lower percentage of CD4+ T cells and CD25+CD4+ regulatory T cells (Supplemental Figure 3D), consistent with the established observation that regulatory T cells do not emerge until after P4 (13).”
Adverse childhood experiences, allostasis, allostatic load, and age-related disease. (2012, background): “During early development, the colonization and infection of the skin, the gastrointestinal tract, and the lungs enable the interaction of microorganisms with T- and B-cells of the acquired immune system [53].”
IgG Placental Transfer in Healthy and Pathological Pregnancies (2011, background): “In addition, responses to some vaccines, such as vaccines for hepatitis B virus and oral poliovirus vaccine, result in less Th1 activity and a bias toward Th2 function [10].”
Innate immunity of the newborn: basic mechanisms and clinical correlates (2007, background): “Given the limited exposure to antigens in utero and the well-described defects in neonatal adaptive immunit”