Identification and classification of chromosomal aberrations in human induced pluripotent stem cells.

By Yoav Mayshar, Uri Ben‐David, Neta Lavon, J. Biancotti, Benjamin Yakir, A. Clark, Kathrin Plath, W. Lowry, N. Benvenisty. Cell Stem Cell, 2010

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Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver (2015, neutral): “, 2007), and iPS cells can harbor considerable numbers of somatic CNVs (Hussein et al., 2011; Laurent et al., 2011; Martins-Taylor et al., 2011; Mayshar et al., 2010; Abyzov et al., 2012).”
The tumorigenicity of human embryonic and induced pluripotent stem cells (2011, background): “A recent study has provided evidence for such chromosomal aberrations, resulting either from the somatic cells of origin or from reprogramming stress, leading to HiPSCs with aberrant karyotypes at early passage”
Epigenetic memory and preferential lineage-specific differentiation in induced pluripotent stem cells derived from human pancreatic islet beta cells. (2011, neutral): “, 2010), genetic stability (Mayshar et al., 2010), stability of imprinted gene expression (Pick et al.”
The promise of induced pluripotent stem cells in research and therapy (2012, background): “In addition, cell lines used in clinical applications will need to be evaluated frequently for aberrant culture-induced changes at all stages: from the somatic cells to the reprogrammed and differentiated cell”
Dynamic Changes in the Copy Number of Pluripotency and Cell Proliferation Genes in Human ES and iPS Cells during Reprogramming and Time in Culture (2011, neutral): “A recent study has reported the use of gene expression data to detect genomic aberrations in a large number of hESCs and hiPSCs (Mayshar et al., 2010).”