Ventral tegmental area neurons in learned appetitive behavior and positive reinforcement.

By H. Fields, G. Hjelmstad, Elyssa B. Margolis, S. Nicola. Annual Review of Neuroscience, 2007

636 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8b1169f2c63e661c1897d1676d35ce2670df0356

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Citations in the corpus

Reward and aversion in a heterogeneous midbrain dopamine system (2013, background): “Approximately 20–40% of VTA cells are GABAergic (Carr and Sesack, 2000a; Margolis et al., 2012; Nair-Roberts et al., 2008), which not only form local contacts onto both DA and non-DA VTA neurons (Omelchenko and Sesack, 2009) but also project to several forebrain regions (Fields et al., 2007).”
Affective neuroscience of pleasure: reward in humans and animals (2008, background): “Cellular and molecular studies of long-term potentiation (LTP) and long-term depression (LTD) of neurotransmission onto neuronal targets of dopamine add ostensible mechanisms for prediction and learning about rewards that give pleasure (Berke 2003; Fields et al. 2007; Hyman et al. 2006; Kelley 2004;”
Circuit Architecture of VTA Dopamine Neurons Revealed by Systematic Input–Output Mapping (2015, background): “In addition to DA neurons, the VTA contains neurons that release GABA, glutamate, and their various combinations, all of which form local and long-range connections (Swanson, 1982; Fields et al., 2007; Morales and Root, 2014; Root et al., 2014).”
The mysterious motivational functions of mesolimbic dopamine. (2012, neutral): “DA release may set a threshold for worthwhile cost expenditures, and under some circumstances may provide an opportunistic drive for exploitation of resources (Fields et al., 2007; Gan et al., 2010; Beeler et al., 2012).”
Functional magnetic resonance imaging in consumer research: A review and application (2011, background): “, a chemical that carries communication signals between brain cells), dopamine modulates decision making, and the involvement of the VTA in motivation has been well established (Fields et al., 2007).”
Computational models of reinforcement learning: the role of dopamine as a reward signal (2010, background): “Experimental data has shown that a single-pulse stimulation applied to the VTA or the median forebrain bundle leads to a DA release lasting a few seconds (Kilpatrick et al. 2000; Fields et al. 2007; Phillips et al. 2003; Robinson et al. 2002; Roitman et al. 2004; Yavich and MacDonald 2000).”
Recombinase-driver rat lines: tools, techniques, and optogenetic application to dopamine-mediated reinforcement (2011, neutral): “Electrical ICSS experiments have been difficult to interpret in the context of phasic DA neuron activation since electrical stimulation activates a heterogeneous and complex population of neurons (Margolis et al., 2006; Fields et al., 2007; Dobi et al., 2010; Lammel et al., 2008; Histed et al., 2009”
Activation of VTA GABA neurons disrupts reward consumption (2012, neutral): “The Ventral Tegmental Area (VTA) is a heterogeneous brain structure containing neuronal populations that are essential for the expression of motivated behaviors and actions related to addiction and other neuropsychiatric illnesses (Fields et al., 2007; Luscher and Malenka, 2011; Nestler and Carlezon”
Shape shifting pain: chronification of back pain shifts brain representation from nociceptive to emotional circuits. (2013, background): “, 2012), and is more generally involved in emotionally learned motivated behaviour (Reynolds and Berridge, 2002; Fields, 2006; Berridge, 2007; Fields et al., 2007).”
GABA Neurons of the VTA Drive Conditioned Place Aversion (2012, background): “This mirrors the established role of the VTA in reward processing (Fields et al., 2007; Schultz, 2010).”
Cortico-Basal Ganglia Reward Network: Microcircuitry (2009, neutral): “Dopamine and particularly its projections to the ventral striatal complex are strongly implicated in the facilitation of approach behaviors and incentive learning (Horvitz, 2000; Wise, 2004; Fields et al, 2007; Ikemoto, 2007; Schultz, 2007; Redgrave et al, 2008).”