mDia mediates Rho-regulated formation and orientation of stable microtubules

By Alexander F. Palazzo, T. Cook, A. Alberts, G. Gundersen. Nature Cell Biology, 2001

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Nuclear movement regulated by Cdc42, MRCK, myosin, and actin flow establishes MTOC polarization in migrating cells. (2005, neutral): “Total cell extracts prepared in SDS sample buffer were analyzed by Western blotting as previously described (Palazzo et al., 2001a).”
The role of the Rho GTPases in neuronal development. (2005, background): “…action of mDia seems to be exerted through its effect on microtubule alignment (Ishizaki et al. 2001), and recent evidence shows that Dia proteins function as downstream effectors of RhoA to regulate the formation and orientation of stable microtubules (Ishizaki et al. 2001; Palazzo et al. 2001).”
Rho GTPases: biochemistry and biology. (2005, background): “It is not clear how stabilization occurs; it appears to be mediated by mDia but does not involve changes to the actin cytoskeleton (Palazzo et al. 2001).”
Cell migration: Rho GTPases lead the way. (2004, background): “Later, Rho was shown to promote the stabilization of microtubules through its target mDia that directly interacts with microtubules and promotes their capping (Ishizaki et al., 2001; Palazzo et al., 2001a).”