An mRNA structure that controls gene expression by binding FMN

By W. Winkler, Smadar Cohen-Chalamish, Ronald R. Breaker. Proceedings of the National Academy of Sciences of the United States of America, 2002

693 citations recorded by the source corpus.

Subfields: Ecology, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8a53ace8ce2d6f27cdfaed5765a8bec39e0f6a2f

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Citations in the corpus

Enhanced annotations and features for comparing thousands of Pseudomonas genomes in the Pseudomonas genome database (2015, methodology): “We also provide inverted repeats identified using the palindrome program from EMBOSS (28) for all isolates in the database which can be useful for identification of regulatory regions such as riboswitches (29) and sites responsible for mediating genome rearrangements (30).”
Control of gene expression by a natural metabolite-responsive ribozyme (2004, background): “However, it has been determined recently that specialized domains within certain mRNAs selectively bind metabolites and control gene expression without the need for protein factor”
Recent advances in RNA structurome (2022, background): “…alternative RNA tertiary fold containing multiple long-range interactions followed by a stable sequester stem unfavorable to translation initiation, thus negatively regulating the expression of genes associated with FMN biosynthesis (Howe et al., 2015; Serganov et al., 2009; Winkler et al., 2002b).”
Alternative RNA Conformations: Companion or Combatant (2022, background): “The FMN riboswitch regulates the expression of metabolite biosynthetic genes in a metabolite-concentration-dependent manner [26].”
Regulation of translation via mRNA structure in prokaryotes and eukaryotes. (2005, background): “In some recently discovered cases, a conformational change in the mRNA is induced by small metabolites or a change in temperature (Chowdhury et al., 2003; Johansson et al., 2002; Nahvi et al., 2004; Nou and Kadner, 2000; Ravnum and Andersson, 2001; Winkler et al., 2002).”
Gene regulation by riboswitches (2004, background): “This level of proof of the existence of TPP- and FMN-dependent riboswitche”
RNA origami scaffolds facilitate cryo-EM characterization of a Broccoli–Pepper aptamer FRET pair (2023, background): “RNA molecules have the ability to fold into complex structures with binding and catalytic properties such as smallmolecule binding RNAs (1), riboswitches (2,3) and ribozymes (4,5).”
Riboswitches and the RNA world. (2012, neutral): “subtilis (Winkler et al. 2002a).”