Forcing cells to change lineages

By Thomas Graf, Tariq Enver. Nature, 2009

908 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8a220a4a285a69e63e87d5175fba67fd81d155e2

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Citations in the corpus

Transcriptional Amplification in Tumor Cells with Elevated c-Myc (2012, positive): “Transcription factors such as the myogenic regulator MyoD or the pluripotency regulators Oct4 and Sox2, when newly expressed at high levels in cells, will bind and establish new enhancers thatmodify theexpressionprogramandalter cell state (Graf and Enver, 2009).”
Super-enhancers in the control of cell identity and disease. (2013, positive): “…regulatory circuitry of cells, and to facilitate efforts to reprogram cells for regenerative medicine, it would be valuable to identify the master transcription factors that control all cell states (Cherry and Daley, 2012; Graf and Enver, 2009; Lee and Young, 2013; Zhou et al., 2008).”
The repair Schwann cell and its function in regenerating nerves (2016, background): “Such cell type conversions are generally referred to as transdifferentiation or direct (or lineage) reprogramming (Graf & Enver, 2009; Sisakhtnezhad & Matin, 2012).”
Enhancer decommissioning by LSD1 during embryonic stem cell differentiation (2012, neutral): “Of the 2,755 LSD1-occupied enhancers with decreased levels of H3K4me1 on differentiation, 63% (1,722) had higher H3K4me1 levels after TCP treatment (P , 10(216)).”
Mapping Transcriptomic Vector Fields of Single Cells (2022, positive): “Arguably, those top genes can be prioritized as TF cocktails for optimal reprogramming between any cell types, paving the road for à la carte reprogramming (Graf and Enver, 2009) for regenerative medicine.”
A Myc rather than core pluripotency module accounts for the shared signatures of embryonic stem and cancer cells (2010, neutral): “between Embryonic Stem and Cancer”
Nuclear reprogramming to a pluripotent state by three approaches (2010, background): “For a comprehensive review of such trans -differentiation induced by transcription factors, see ref”
Implications of the Hybrid Epithelial/Mesenchymal Phenotype in Metastasis (2015, background): “Transdifferentiation often requires a large external signal such as overexpression of some cell-fate “master regulator” TFs (37, 38).”
Control of Embryonic Stem Cell State (2011, background): “Reprogramming and transdifferentiation experiments support the idea that a small number of master transcription factors can control cell state in various cell types (Graf and Enver, 2009; Vierbuchen et al., 2010; Zhou et al., 2008a).”
Transcriptional Addiction in Cancer (2017, neutral): “, 2009), a small number of master TFs, sometimes called lineage regulators, are sufficient to establish control of the gene expression programs that define cell identity (Buganim et al., 2013; Graf and Enver, 2009; Lee and Young, 2013; Morris and Daley, 2013; Sancho-Martinez et al., 2012; Vierbuchen”
Dynamic reprogramming of chromatin accessibility during Drosophila embryo development (2011, background): “Background The progressive restriction of cellular fate is a hallmark of development and is believed to involve the sequential modification and perpetuation of chromatin states [1].”
Master Transcription Factors Determine Cell-Type-Specific Responses to TGF-β Signaling (2011, positive): “Transcription factors bind specific DNA sequences and regulate gene expression (Ptashne, 1988), and master transcription factors are required for establishment, maintenance, and even reprogramming of cell identity (Takahashi and Yamanaka, 2006; Feng et al., 2008; Lassar et al., 1986; Seale et al., 2”
Somatic cell reprogramming and transitions between pluripotent states: facts, hypotheses, unresolved issues (2010, neutral): “Here transdifferentiation is defined as the direct conversion of one somatic cell type into another typewithout first reprogramming into pluripotent cells and then differentiating into 520 Cell 143, November 12, 2010 ª2010 Elsevier Inc. functional somatic cells (Graf and Enver, 2009).”
Integrated single-cell analysis maps the continuous regulatory landscape of human hematopoietic differentiation (2018, background): “Low level expression of lineage specifying TFs in other multipotent cell systems has been described (Grün et al., 2016) and is hypothesized to generally promote multipotency (Graf and Enver, 2009), which may also explain the low level TF Z scores in this analysis of HSCs.”