Somatotopic organisation of the human insula to painful heat studied with high resolution functional imaging

By Jonathan C W Brooks, L. Zambreanu, A. Godinez, A. Craig, Irene Tracey. NeuroImage, 2005

349 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Cognitive Neuroscience, Physiology

View Paper: https://www.semanticscholar.org/paper/894a4579470f3e75c1b2709a5e1123fd529dce2e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cardiology and Cardiovascular Medicine

1. Tor D. Wager

In Cognitive Neuroscience

1. Michael P. Milham
2. F. X. Castellanos
3. A. di Martino
4. Clare Kelly
5. Tor D. Wager
6. Colin Klein
7. Andrew B. Barron
8. Ethan Kross

In Physiology

1. Tor D. Wager
2. Edward E. Smith
3. B. Key
4. Bjorn H. Merker
5. David A. Seminowicz
6. David P. Finn
7. Ethan Kross
8. Walter Mischel

Citations in the corpus

• Social rejection shares somatosensory representations with physical pain (2011, background): “electrical stimulation study of the insula (19); and (ii) the mirror site on the left hemisphere (−34, −14, 19).”
• The neurobiology of itch (2006, background): “, but might be much clearer in the dorsal posterior insul”
• The neural correlates of tinnitus-related distress (2010, positive): “Unpleasantness of pain activates the anterior cingulate and prefrontal cortices (Mobascher et al., 2009), amygdala, and insula (Brooks et al., 2005).”
• A Convergent Functional Architecture of the Insula Emerges Across Imaging Modalities (2012, positive): “…interoception (including satiety and craving; e.g., Critchley et al., 2004; Naqvi and Bechara, 2009), somesthesis (including nociception; e.g., Brooks et al., 2005; Starr et al., 2009), somatic control (including the regulation of cardioregulatory, vasomotor and visceromotor function; e.g.,…”
• Insects have the capacity for subjective experience (2016, background): “Somatotopic maps of noxious stimuli also exist in the anterior and posterior insular cortex (Brooks et al., 2005; Baumgartner et al., 2010).”
• Why fish do not feel pain (2016, background): “Somatotopic maps of noxious stimuli also exist in the anterior and posterior insular cortex (Brooks et al., 2005; Baumgartner et al., 2010).”
• Consciousness without a cerebral cortex: A challenge for neuroscience and medicine (2007, background): “This reasoning, however, ignores clinical data showing that ablation or stimulation of somatosensory cortex does not alter pain perception in adults, whereas thalamic ablation or stimulation does (Brooks et al. 2005; A. D. Craig 2003; Nandi et al. 2003).”
• Two systems of resting state connectivity between the insula and cingulate cortex (2009, background): “Thus, the anterior insula included the anterior short gyrus, the midinsula included the middle and posterior short gyrus, and the posterior insula included the anterior long gyrus (Brooks et al., 2002; Brooks et al., 2005; Schweinhardt et al., 2006).”
• Functional connectivity of the insula in the resting brain (2011, positive): “…visual, verbal, pain, sensory/ motor information, and inputs related to music and eating, and modulating attention and emotion; (Augustine, 1996; Brooks et al. 2005; Cole et al., 2006; Craig, 2002, 2003, 2004; Critchley et al., 2004 Devinsky et al., 1995; Lamm and Singer, 2010; Mutschler et…”
• The effect of pain on cognitive function: a review of clinical and preclinical research. (2011, background): “The IC shows somatotopic organisation (Brooks et al., 2005), is a component of the limbic system, and is activated by the experience of emotions such as happiness, sadness, anger, fear and disgust (Damasio et al.”