Proteomic Analysis of Dendritic Cell-Derived Exosomes: A Secreted Subcellular Compartment Distinct from Apoptotic Vesicles1

By C. Théry, Muriel Boussac, P. Véron, P. Ricciardi-Castagnoli, G. Raposo, J. Garin, S. Amigorena. Journal of Immunology, 2001

1,563 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/88bfdc5c1c4f3bdd5479f796a91a2d3d982244c1

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Citations in the corpus

Exosomes: extracellular organelles important in intercellular communication. (2010, methodology): “[20] Thery C, Boussac M, Veron P, Ricciardi-Castagnoli P, Raposo G, Garin J, Amigorena S.”
Exosomes as new vesicular lipid transporters involved in cell-cell communication and various pathophysiologies. (2014, background): “Exosomes are also totally distinct from apoptotic microparticles [12] which bear markers such as CD31 (endothelial cellular adhesion molecule) and CD105 (endoglin, TGFβ co-receptor) [35,36].”
Introduction to Extracellular Vesicles: Biogenesis, RNA Cargo Selection, Content, Release, and Uptake (2016, neutral): “Comprehensive research has been done on the protein cargo of EVs, profiling the contents of different-sized vesicles produced by various cell types (Conde-Vancells et al. 2008; Demory Beckler et al. 2013; Gonzalez-Begne et al. 2009; Graner et al. 2009; Théry et al. 2001; Turiák et al. 2011).”
Review of the Isolation, Characterization, Biological Function, and Multifarious Therapeutic Approaches of Exosomes (2019, background): “Proteomics analysis of exosomes and apoptotic vesicles shows the differential enrichment of proteins between each vesicle type and an increase in the number of vesicles in apoptotic cells [146].”
Tetraspanins in Extracellular Vesicle Formation and Function (2014, background): “EVborne proteins are processed by DCs into peptides that associate to MHC molecules for eventual presentation to T lymphocytes (125–127).”
TCR Activation of Human T Cells Induces the Production of Exosomes Bearing the TCR/CD3/ζ Complex1 (2002, methodology): “The CD4 T cell-derived exosomes we described in this study bear the TCR/CD3 complex as well as molecules, such as CD2 and CD18, which are implicated in cell adhesion.”
Extracellular vesicles: Exosomes, microvesicles, and friends (2013, background): “How cytosolic constituents are recruited into exosomes is unclear but may involve association of exosomal membrane proteins with chaperones such as Hsc70, that are found in exosomes from most cell types (Théry et al., 2001; Géminard et al., 2004).”