TCR Activation of Human T Cells Induces the Production of Exosomes Bearing the TCR/CD3/ζ Complex1

By N. Blanchard, D. Lankar, F. Faure, A. Régnault, C. Dumont, G. Raposo, C. Hivroz. Journal of Immunology, 2002

677 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/dd2214bf7642e0e9758c7ebb543513be1ee68814

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Citations in the corpus

Tetraspanins in Extracellular Vesicle Formation and Function (2014, background): “Others studies have shown the essential role of tetraspanin CD63 in the biogenesis of lysosome-related organelles (75), although exosome secretion was not directly assessed. shRNA knockdown of the tetraspanin protein CD63 in a B lymphoblastoid APC line led to increased CD4 T cell activation because ”
Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. (2014, background): “Finally, some cells, such as B or T lymphocytes, secrete very little EVs at the steady state, but MVB-derived exosome secretion is strongly enhanced by activation through interactions with T cells (Blanchard et al. 2002, Mittelbrunn et al. 2011) or the B cell receptor (Muntasell et al. 2007).”
The Biogenesis and Functions of Exosomes (2002, background): “Similarly, in other cell types, including T lymphocytes (29,36), B lymphocytes, platelets and DCs, fusion of MVBs with the plasma membrane may also be stimulated through increased cytosolic Ca2π.”
Exosome-Based Cell-Cell Communication in the Tumor Microenvironment (2018, background): “Therefore, it has been suggested that such exosomes are able to modulate lymphocyte functions by mimicking “activation-induced cell death” (AICD) (Blanchard et al., 2002; Perone et al., 2006; Taylor and Gercel-taylor, 2011).”
Human saliva, plasma and breast milk exosomes contain RNA: uptake by macrophages (2011, background): “Many cells in the body have the capacity to produce and release exosomes to their surrounding environment, including dendritic cells, B cells, T cells, mast cells, tumour cells and epithelial cells [2-7].”
Exosomes: vehicles of intercellular signaling, biomarkers, and vectors of cell therapy. (2015, background): “Many exosomes contain major histocompatibility complex (MHC) class I and class II molecules (37, 38) that are involved in antigen binding and presentation.”
Lipid raft-associated protein sorting in exosomes. (2003, background): “and (5) the heterotrimeric G protein -subunit (G i2) is present in reticulocyte exosomes.”