A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling.

By F. Chan, Hyung J. Chun, Lixin Zheng, R. Siegel, Kimmie L. Bui, M. Lenardo. Science, 2000

907 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/8890e2d03432a6d1b3c5c923f4a03c5d79bf57fc

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Citations in the corpus

CD95's deadly mission in the immune system (2000, background): “To prevent the premature signalling of preassociated receptors, which is a dangerous situation, intracellular receptor-associated apoptosis blockers were postulate”
Proteases for Cell Suicide: Functions and Regulation of Caspases (2000, background): “Fas molecules preassemble into homotrimers via the preligand-binding assembly domain in the extracellular regions (19, 186).”
Signalling pathways of the TNF superfamily: a double-edged sword (2003, background): “cgi?l=7133">TNFR2 has been identified that mediates specific ligand-independent assembly of receptor trimer”
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease. (2014, background): “Common features in this region include four cysteine-rich domains (CRDs), each of which comprises three cysteine-cysteine disulphide bonds, and a preligand binding assembly domain (PLAD) involved in trimerisation of the receptor [33].”
Molecular mechanisms of necroptosis: an ordered cellular explosion (2010, background): “In the absence of TNF, TNFR1 subunits spontaneously assemble at the plasma membrane to generate trimeric receptors owing to the so-called pre-ligand assembly domain (PLAD), which is localized in the extracellular Cys-rich domain 1 (CRD1) of the protei”
TNF and TNF-receptors: From mediators of cell death and inflammation to therapeutic giants - past, present and future. (2014, background): “homotypic interactions that facilitate ligand binding-induced TNFR signaling [50].”
Tumor necrosis factor antagonist mechanisms of action: a comprehensive review. (2008, background): “Trimers of receptor chains preassemble on the cell surface prior to ligand binding, owing to associations between TNF-receptor, subtype-specific, pre-ligand–binding assembly domains (Chan et al., 2000).”
Life and death by death receptors (2009, background): “Although PLAD is not directly involved in ligand binding, deletion of PLAD severely compromises ligand binding to TNFR-1, suggesting that preligand assembly of the receptors is a crucial step for the receptor-ligand interaction (11).”