Molecular Basis for High Virulence of Hong Kong H5N1 Influenza A Viruses

By M. Hatta, Peng Gao, P. Halfmann, Yoshihiro Kawaoka. Science, 2001

1,390 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/88281c7af2ac6d41e96eb307592f872419bd32d5

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Yi Guan
2. J. Steel
3. Anice C. Lowen
4. P. Palese
5. J. Peiris
6. M. D. de Jong
7. S. Mubareka
8. Yoshihiro Kawaoka

In Molecular Biology

1. Yi Guan
2. C. Karp
3. Guangchuang Yu
4. A. Varki

Citations in the corpus

• Transmission of Influenza Virus in a Mammalian Host Is Increased by PB2 Amino Acids 627K or 627E/701N (2009, result): “In addition, contrary to recent findings in mice [12], we did not observe marked differences in the viral titers reached by rVN1203 wild-type, rVN1203 627E and rVN1203 627E 701N viruses in the upper respiratory tract of guinea pigs.”
• Avian Influenza Virus (H5N1): a Threat to Human Health (2007, background): “Virus virulence and dissemination in the BALB/c mouse model is determined by the amino acid replacements in the PB2 gene at position 627 (Lys) or 701 (Asn) and the presence of a multibasic amino acid motif in the HA connecting peptide (76, 128).”
• Furin at the cutting edge: From protein traffic to embryogenesis and disease (2002, background): “Analysis of the H5N1 influenza virus, which killed at least six people, showed that just two mutations were required to generate the lethal virus — a mutation in a subunit of the viral RNA polymerase PB2, together with the generation of a tandem furin site in the cleavage junction between HA 1 and ”
• Experimental adaptation of an influenza H5 haemagglutinin (HA) confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets (2012, neutral): “6 (3) 5 of 5 (40, 20, 20, 40, 40) 0 of 5 0 of 5 (,10, ,10, ,10, ,10, ,10)”
• In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses (2009, background): “8 or 8 mg per kg per 50ml in one daily intranasal administration for 5 days; (3) CS-8958: 0.”