Global analysis of mRNA localization reveals a prominent role in organizing cellular architecture and function.

By E. Lécuyer, H. Yoshida, Neela Parthasarathy, C. Alm, Tomas Babak, T. Cerovina, Timothy R. Hughes, Pavel Tomancak, H. Krause. Cell, 2007

967 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8770f6cf9310a867c3f29690874ac12419b23b9b

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Citations in the corpus

The Central Dogma Decentralized: New Perspectives on RNA Function and Local Translation in Neurons (2013, background): “That localized RNA is more often the rule than the exception is spectacularly illustrated by the finding that 71% of the Drosophila embryo transcriptome is localized to specific subcellular compartments (Lécuyer et al., 2007).”
Inaugural Article: Three-dimensional tracking of single mRNA particles in Saccharomyces cerevisiae using a double-helix point spread function (2010, neutral): “Indeed specific subcellular localization may be a genetically encoded feature of the expression program of most, and perhaps all, mRNAs in complex organisms (29, 30).”
CircInteractome: A web tool for exploring circular RNAs and their interacting proteins and microRNAs (2016, background): “RBPs control all stages of post-transcriptional gene expression, including the splicing, export, turnover, translation, and localization of mRNAs.(7-9) By modulating gene expression, RBPs play key roles in virtually all cellular processes – proliferation, differentiation, motility, senescence, apopt”
Establishment of regions of genomic activity during the Drosophila maternal to zygotic transition (2014, background): “Many of the genes transcribed by cycle 14 are expressed in clear spatial patterns (Lécuyer et al., 2007; Tomancak et al., 2007; Combs and Eisen, 2013) driven by the action of distinct transcriptional enhancers.”
Screening cell–cell communication in spatial transcriptomics via collective optimal transport (2023, methodology): “To test robustness, we used the stage 6 Drosophila embryo, an extensively studied system 58,59 .”
LNCcation: lncRNA localization and function (2021, background): “…form through the process of liquid–liquid phase separation (Courchaine et al., 2016; Weber and Brangwynne, 2012), resulting in well-defined borders while enabling a dynamic exchange of content with the cytoplasm or nucleoplasm (Brangwynne et al., 2009; Lee et al., 2013; Shin and Brangwynne, 2017).”
Deep Model Based Transfer and Multi-Task Learning for Biological Image Analysis (2015, background): “Gene expression patterns and the associated temporal stages and body part keywords in the BDGP [26] (left) and Fly-FISH [17] (right) databases for the gene engrailed in two stage-ranges.”
Large‐scale image‐based screening and profiling of cellular phenotypes (2017, methodology): “The traditional FISH method has also been optimized to allow the imaging of tens to thousands of mRNAs in neurons (17) and the Drosophila embryos (18).”
Genome-wide RNA Tomography in the zebrafish embryo. (2014, background): “spatial patterns of gene expression on a large scale (Fowlkes et al., 2008; Geffers et al., 2012; Gray et al., 2004; Lécuyer et al., 2007; Thisse et al., 2004; Yu et al., 2012).”
Mechanisms and consequences of alternative polyadenylation (2011, positive): “Strikingly, high-resolution in situ hybridization techniques revealed that more than 70% of transcripts in Drosophila embryos are expressed in spatially distinct patterns (Lécuyer et al., 2007).”
Long noncoding RNAs: functional surprises from the RNA world. (2009, background): “Considering the great variety of mRNA localization patterns that are observed during early Drosophila embryogenesis (Lecuyer et al. 2007), it is tempting to speculate that many more RNAs (especially ncRNAs) may have structural and organization roles in the cell.”
mRNA Localization: Gene Expression in the Spatial Dimension (2009, positive): “…the analysis of RNA localization in migrating fibroblasts (Mili et al., 2008), Xenopus oocytes (Blower et al., 2007), and Drosophila embryos (Lecuyer et al., 2007) may reveal subcellular compartments that had previously been unappreciated, and thus these findings may lead to a more detailed…”
The maternal-to-zygotic transition: a play in two acts (2009, methodology): “Microarray-based expression profiling studies – supplemented in D. melanogaster by genome-wide fluorescence in situ hybridization analyses (Lecuyer et al., 2007) – have begun to uncover the scope of ZGA: up to 15% of the genome in D. melanogaster (Benoit et al., 2009; De Renzis et al., 2007;…”
Single-Cell and Single-Molecule Analysis of Gene Expression Regulation (2016, background): “Three hours after fertilization, the Drosophila embryo is composed of ∼6,000 cells with pattern formation information that determines the Drosophila body segments (81).”