mRNA Localization: Gene Expression in the Spatial Dimension

By K. C. Martin, A. Ephrussi. Cell, 2009

1,048 citations recorded by the source corpus.

Summary The localization of mRNAs to subcellular compartments provides a mechanism for regulating gene expression with exquisite temporal and spatial control and recent studies suggest that a large fraction of mRNAs localize to distinct cytoplasmic domains. In this review, we focus on cis-acting RNA localization elements, RNA-binding proteins, and the assembly of mRNAs into granules that are transported by molecular motors along cytoskeletal elements to their final destination in the cell.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/2fa474a1045d402194e7247e3013a39599874910

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

Citations in the corpus

Codon identity regulates mRNA stability and translation efficiency during the maternal‐to‐zygotic transition (2016, neutral): “…with the median indicated with a thick black line and vertical lines indicate the variability outside the upper and lower quartiles. activation, fertilization, or zygotic genome activation, depending on the specific mRNA (Mendez & Richter, 2001; Clark et al, 2007; Yartseva & Giraldez, 2015).”
Single-cell RNA-seq: advances and future challenges (2014, neutral): “However, the localization of mRNAs within sub-cellular compartments is a cellular strategy to regulate gene expression (123), so it would be insightful to sequence cellular transcripts while preserving their natural context.”
Inaugural Article: Three-dimensional tracking of single mRNA particles in Saccharomyces cerevisiae using a double-helix point spread function (2010, neutral): “The localization of mRNA-protein (mRNP) complexes to specific subcellular compartments allows for greater spatial and temporal control of gene expression (28).”
Recent advances in RNA structurome (2022, background): “In addition, stem-loop structures in cisacting RNA elements can also control the specific subcellular localization of mRNAs (Martin and Ephrussi, 2009).”
Principles and Properties of Stress granules (2016, background): “Similarly, stress granule-like RNP granules exist in neurons and embryos where there are significant pools of untranslating mRNPs [17].”
BDNF-induced local protein synthesis and synaptic plasticity. (2014, neutral): “These ribonucleoprotein complexes may combine with other factors to form a functional complex which is transported along the microtubule cytoskeleton to its final destination (Doyle and Kiebler, 2011; Martin and Ephrussi, 2009).”
Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP (2010, background): “Gene expression in eukaryotes is extensively controlled at the posttranscriptional level by RNA-binding proteins (RBPs) and ribonucleoprotein complexes (RNPs) modulating the maturation, stability, transport, editing and translation of RNA transcripts (Martin and Ephrussi, 2009; Moore and Proudfoot, ”
Ribosome Profiling of Mouse Embryonic Stem Cells Reveals the Complexity of Mammalian Proteomes (2011, background): “The biological roles of the pauses we identify remain to be established, but many mRNAs are localized to specific subcellular regions (Martin and Ephrussi, 2009), including a number of mRNAs found on the ER surface that, like Xbp1, do not enter the secretory pathway (Kraut-Cohen A B 0.01% 0.1% 1%…”