The Central Dogma Decentralized: New Perspectives on RNA Function and Local Translation in Neurons
By C. Holt, E. Schuman. 2013
509 citations recorded by the source corpus.
The elaborate morphology of neurons together with the information processing that occurs in remote dendritic and axonal compartments makes the use of decentralized cell biological machines necessary. Recent years have witnessed a revolution in our understanding of signaling in neuronal compartments and the manifold functions of a variety of RNA molecules that regulate protein translation and other cellular functions. Here we discuss the view that mRNA localization and RNA-regulated and localized translation underlie many fundamental neuronal processes and highlight key issues for future experiments.
Subfields: Molecular Biology
How researchers see this paper
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In Molecular Biology
- Michele Vendruscolo
- Tuomas P. J. Knowles
- D. Dormann
- E. Holzbaur
- S. Alberti
- Dennis W. Dickson
- D. Ron
- C. Holt
Citations in the corpus
- AXONAL TRANSPORT: CARGO-SPECIFIC MECHANISMS OF MOTILITY AND REGULATION (2014, background): “Sequences within the 50 and 30 UTR of mRNAs are recognized by RNA-binding proteins and direct transport to either dendrites or the axon (Holt and Schuman, 2013; Merianda et al., 2013).”
- FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions (2018, background): “These dynamic structures take up, sequester, transport, and then release key RNA and protein cargos that regulate local RNA and protein metabolism in subcellular niches, such as axon terminals and dendrites (Holt and Schuman, 2013; Sephton and Yu, 2015).”
- ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function (2015, background): “…is to disrupt the function of cytoplasmic RNP granules, thereby reducing new protein synthesis in intracellular compartments, such as axon terminals, that are heavily dependent on local translation control by RNP granules (Akbalik and Schuman, 2014; Holt and Schuman, 2013; Jung et al., 2014).”
- Liquid-Liquid Phase Separation in Disease. (2019, background): “This is achieved through highly complex posttranscriptional gene regulation, including high levels of alternative splicing, RNA editing, messenger RNA (mRNA) transport, and local translation in axons and dendrites (73, 87).”