TAT peptide on the surface of liposomes affords their efficient intracellular delivery even at low temperature and in the presence of metabolic inhibitors

By Vladimir Torchilin, Ram Rammohan, V. Weissig, Tatyana Levchenko. Proceedings of the National Academy of Sciences of the United States of America, 2001

791 citations recorded by the source corpus.

Subfields: Molecular Biology, Virology

View Paper: https://www.semanticscholar.org/paper/86d1eb64b27cdd5873e88ed5c605d460fd1b3fee

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In Molecular Biology

1. S. Sahoo
2. J. Wadia
3. S. Dowdy
4. Vladimir Torchilin
5. P. Cullis
6. Jianxiu Xue
7. Shan Gao
8. Yan Fang

In Virology

1. Vladimir Torchilin

Citations in the corpus

• Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion proteins after lipid raft macropinocytosis (2004, background): “Taken together, these observations showing rapid transduction into cells, dynamin-1-independence, inhibition of uptake by amiloride and cytochalasin D, and variable cargo sizes (peptides to iron bead”
• Basics and recent advances in peptide and protein drug delivery (2013, neutral): “Unfortunately, PEGylation of CPPmodified liposomes appears to decrease the effectiveness of the CPP [209].”
• Cell junction dynamics in the testis: Sertoli-germ cell interactions and male contraceptive development. (2002, background): “Alternatively, this peptide can be conjugated to protein transduction domains (PTDs), small peptides of 10–16 residues having numerous positively charged lysine and arginine residues (185, 195, 398, 399, 453), for delivery.”
• Cellular uptake of arginine-rich peptides: roles for macropinocytosis and actin rearrangement. (2004, background): “For example, it was reported that liposomes containing surface Tat peptides entered the cells as intact structures without fusion with the plasma membrane [17].”
• Liposomal drug delivery systems: from concept to clinical applications. (2013, background): “brane to result in the cytoplasmic delivery of the drug cargo [95–99], but this approach has not been widely adapted.”
• Rapid endo‐lysosomal escape of poly(DL‐lactide‐coglycolide) nanoparticles: implications for drug and gene delivery (2002, background): “... including the poor permeability and selectivity of cell membranes and degradation of the macromolecules in the lysosomes following their internalization by endocytosis (1, 2). Thus, in recent years there has been significant interest in developing carriers for intracellular delivery that will en”
• Cleavable PEGylation: a strategy for overcoming the “PEG dilemma” in efficient drug delivery (2017, background): “Among these carriers, TAT peptide is inserted into the PEG chain which can increase the uptake rate of the cells (Torchilin et al., 2001, 2003; Fretz et al., 2004; Vandenbroucke et al., 2007).”
• Delivery of therapeutic agents to the central nervous system: the problems and the possibilities. (2004, background): “It has been suggested that the TAT peptide induces the formation of reverse micelles as an energy-independent process (Torchilin et al., 2000), as low temperature and metabolic inhibitors appear to have no influence on the process, and it is also suggested that cell surface receptors play no part in”
• Recent advances with liposomes as pharmaceutical carriers (2005, background): “It has been demonstrated that relatively large particles, such as liposomes, can be delivered into various cells by several TAT-peptide or other CPP molecules attached to the liposome surfac”