Delivery of therapeutic agents to the central nervous system: the problems and the possibilities.

By D. Begley. Pharmacology and Therapeutics, 2004

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Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging (2009, background): “While most endothelial barriers allow NPs 150 nm in diameter to pass, more stringent barriers, such as the BBB are far more restrictive.”
Crossing the blood‐brain barrier with nanoparticles (2018, background): “From the anatomic point of view, the BBB is composed of five constituent parts, namely the pericytes, astrocytes, neurons, basement membrane, and junctional complexes [7,8].”
Structure and function of the blood-brain barrier. (2010, background): “These substances and many of their metabolites are actively effluxed from the brain and the capillary endothelium forming the BBB by members of the ABC transporter (ATP-binding cassette) family (Begley, 2004b) (Table 3 and Fig.”
3D Self-Organized Microvascular Model of the Human Blood-Brain Barrier with Endothelial Cells, Pericytes and Astrocytes (2018, background): “6e and f), confirming barrier selectivity depending on their molecular weight [59].”