Catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression

By E. Batlle, J. Henderson, Harry Beghtel, M. V. D. Born, E. Sancho, G. Huls, J. Meeldijk, J. Robertson, M. Wetering, Tony Pawson and 1 more. 2002

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Wnt signaling in the intestinal epithelium: from endoderm to cancer. (2005, background): “The tyrosine kinase receptors EphB2 and EphB3 and their ligand ephrin B1 illustrate this point (Batlle et al. 2002).”
The intestinal crypt, a prototype stem cell compartment. (2013, background): “In EphB3 / mice, Paneth cells fail to home efficiently to the crypt base but tend to comigrate with all other cells toward the villus tip (Batlle et al., 2002).”
SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes (2004, background): “The Wnt pathway also regulates the expression of the Eph/ Ephrin surface molecules, responsible for the ordered positioning of epithelial cells along the crypt-villus axis (Batlle et al., 2002).”