Salmonella induces macrophage death by caspase‐1‐dependent necrosis

By Molly A. Brennan, B. Cookson. Molecular Microbiology, 2000

688 citations recorded by the source corpus.

Subfields: Immunology, Infectious Diseases, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8600c9201821c0ff2614c16073f1c28ec9d303cb

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Citations in the corpus

The inflammasome: an integrated view (2011, background): “The first evidence for this phenomenon came from the study of an unusual type of cell death that follows macrophage infection with Salmonella typhimurium (126, 127).”
Classification of cell death (2005, neutral): “Pyroptosis has first been described in macrophages infected with Salmonella typhimurium.(73) It involves the apical activation of caspase-1 (but not of caspase-3), a protease that is mostly known as interleukin1b (IL-1b)-converting enzyme.”
Neuronal Cell Death. (2018, neutral): “Pyroptosis is a form of regulated necrosis mediated by caspase-1 (FIGURE 9) and first described in macrophages infected by intracellular bacteria (68).”
Mechanisms of ferroptosis (2016, background): “RCD can proceed through apoptosis or one of several non-apoptotic cell death pathways, including the recently described process of ferroptosis [1–5].”
NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation and fibrosis (2014, background): “However, in contrast to apoptosis, pyroptosis is also associated with cell swelling, release of pro-inflammatory intracellular contents and pore formation in the cell membrane, thereby becoming positive for propidium iodide (PI) staining.(13-14)”
Caspase‐1‐dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages (2006, methodology): “PARP is cleaved and inactivated during apoptosis (Herceg and Wang, 2001), but remains in its active, uncleaved state in S. Typhimurium-infected macrophages (Brennan and Cookson, 2000).”
Broad targeting of resistance to apoptosis in cancer (2015, background): “For example, HIV-1 shows to kill CD4+T lymphocytes by necrosis [87] and Shigella and Salmonella can induce necrotic cell death of infected neutrophils and macrophages [88].”
Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death. (2017, background): “typhimurium-induced macrophage deaths are indeed necrotic, despite some neglected voices arguing for the latter [72,73].”
From pyroptosis, apoptosis and necroptosis to PANoptosis: A mechanistic compendium of programmed cell death pathways (2021, background): “These differences led to the introduction of the term pyroptosis [58,59].”
Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012 (2011, background): “Moreover, in some (but not all) instances, this is followed by caspase activation and cell death.(143) Active caspase-1 reportedly mediates the proteolytic activation of caspase-7 (rather than that of caspase-3),(155) suggesting that pyroptotic cell death might proceed via an unusual caspase-1-caspa”
Necrosis, a well-orchestrated form of cell demise: signalling cascades, important mediators and concomitant immune response. (2006, background): “HIV-1 was shown to kill CD4 T lymphocytes by necrosis [221–223] and Shigella and Salmonella can induce necrotic cell death of infected neutrophils and macrophages, respectively [224,225].”