DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells.
By Teunis B. Geijtenbeek, D. Kwon, R. Torensma, S. J. Vliet, G. Duijnhoven, J. Middel, I. Cornelissen, H. Nottet, V. KewalRamani, Dan R. Littman and 2 more. Cell, 2000
2,590 citations recorded by the source corpus.
Subfields: Immunology, Virology
View Paper: https://www.semanticscholar.org/paper/85fef048bceffdaf96488b8e8445cfd2cf3b0160
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Immunology
- R. Steinman
- Teunis B. Geijtenbeek
- Y. Kooyk
- M. Marsh
- Olivier Schwartz
- Hidde L. Ploegh
- Ari Helenius
- A. Lanzavecchia
In Virology
Citations in the corpus
- From carbohydrate leads to glycomimetic drugs (2009, methodology): “The amino-acid sequence of DC-SIGN is identical to a previously described HIV glycoprotein 120 (gp120)-binding C-type lecti”
- Signalling through C-type lectin receptors: shaping immune responses (2009, background): “Therapeutic potential of CLR signalling The interaction of several CLRs with pathogens promotes infection by virus disseminatio”
- Microbial stimulation fully differentiates monocytes to DC-SIGN/CD209+ dendritic cells for immune T cell areas (2010, methodology): “DC-SIGN is a hallmark of human Mo-DCs in culture (Geijtenbeek et al., 2000b) but is not detected on the rich network of presumably monocyte-independent DCs in human LNs in the steady state (Granelli-Piperno et al., 2005).”
- Mycobacteria Target DC-SIGN to Suppress Dendritic Cell Function (2003, background): “Rapid internalization of ManLAM by DC-SIGN suggests that DC-SIGN may also be involved in mycobacterial uptake by DCs, as was shown for HIV-1 (10).”
- DC-SIGN Is the Major Mycobacterium tuberculosis Receptor on Human Dendritic Cells (2003, background): “This has also been suggested for HIV (17), and might account for several pathological and immunological aspects of M. tuberculosis infection, e.g., mediastinal adenitis, the formation of secondary granulomas in the LNs, and the chronic stimulation of the immune system that is required to maintain th”
- Virus Entry: Open Sesame (2006, positive): “Recent studies have suggested an alternative mode of interaction whereby viruses may be captured by C type lectins (Geijtenbeek et al., 2000; Turville et al., 2002), and perhaps other receptors involved in antigen acquisition, and internalized into endocytic vesicles without infecting the dendritic ”
- The known unknowns of antigen processing and presentation (2008, background): “For example, DCs can be infected with HIV-1 through the cell-surface receptor DC-specific intracellular adhesion molecule 3-grabbing non-integrin (DC-SIGN), and HIV-1 is internalized by endocytosis in a form that retains the viability of the virus and allows its transfer to T cells, possibly through”
- Cellular immune responses to HIV (2001, background): “In the periphery, HIV binds to DC-SIGN, a glycoprotein expressed on dendritic cells, without infecting the”