Virus Entry: Open Sesame

By M. Marsh, Ari Helenius. Cell, 2006

1,184 citations recorded by the source corpus.

Detailed information about the replication cycle of viruses and their interactions with host organisms is required to develop strategies to stop them. Cell biology studies, live-cell imaging, and systems biology have started to illuminate the multiple and subtly different pathways that animal viruses use to enter host cells. These insights are revolutionizing our understanding of endocytosis and the movement of vesicles within cells. In addition, such insights reveal new targets for attacking viruses before they can usurp the host-cell machinery for replication.

Subfields: Cell Biology, Genetics, Virology

View Paper: https://www.semanticscholar.org/paper/a3be3787c3077138b0f38f4c7ce4a54b61bc392a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. Ari Helenius
2. Jason Mercer
3. Harald A. Stenmark
4. Q. Sattentau
5. M. Saxton
6. S. Mayor
7. G. Meer
8. P. Couvreur

In Genetics

1. Q. Sattentau
2. M. Saxton
3. Jason Mercer
4. Harald A. Stenmark
5. P. Couvreur
6. Ari Helenius
7. Huajian Gao

In Virology

1. Jason Mercer
2. Q. Sattentau
3. M. Saxton
4. Harald A. Stenmark
5. Ari Helenius

Citations in the corpus

• HIV Enters Cells via Endocytosis and Dynamin-Dependent Fusion with Endosomes (2009, neutral): “Endocytosis is an obligatory entry step for enveloped viruses whose fusion proteins are activated by acidic pH ( Marsh and Helenius, 2006 ).”
• Virus Entry by Endocytosis (2013, neutral): “Either scenario is predicted to raise serious threats worldwide, as was the case in 1957 and 1968 [17, 18].”
• SINGLE-PARTICLE TRACKING (2009, background): “Single-particle tracking of viruses is reviewed by Brandenburg and Zhuang [150] and the mechanism of viral infection by Damm and Pelkmans [151], Marsh and Helenius [152], Radtke et al.”
• Membrane lipids: where they are and how they behave (2008, background): “Pathological processes such as viral infection have been unexpectedly connected to specific membrane lipids and their biophysical propertie”
• Invasive and Adherent Bacterial Pathogens Co-Opt Host Clathrin for Infection (2007, neutral): “However, the invasion of some viruses (e.g., parvovirus, influenza, or reovirus), which are well known to enter host cells by clathrin-dependent endocytosis (Ehrlich et al., 2004; Marsh and Helenius, 2006 ), has been reported to occur through vesicles larger that 150 nm (Matlin et al., 1981; Parker”
• HIV: cell binding and entry. (2012, background): “Many viruses require delivery by the host cell into an acidic, intracellular compartment where low pH triggers membrane-fusion-inducing conformational changes (reviewed in Marsh and Helenius 2006).”
• Physical Principles of Nanoparticle Cellular Endocytosis. (2015, background): “Clathrinmediated endocytosis is the most common endocytic pathway exploited by viruses.(24,25) Caveolin-dependent endocytosis (Figure 1c) involves the assembly of the hairpin-like caveolin coats on the cytosolic side of the plasmamembrane, forming a flask-shaped caveolae of ∼50 80 nm in diameter.”
• Rab GTPases as coordinators of vesicle traffic (2009, background): “A large group of viruses enter cells through various endocytic pathways, and some viruses hijack Rab-dependent pathways to induce their own internalizatio”
• Autophagy and lysosomal dysfunction as emerging mechanisms of nanomaterial toxicity (2012, background): “lysosomes, pathogens have been shown to take advantage of this pathway to escape lysosomal enzymatic degradation [17,18].”
• Avoiding the void: cell-to-cell spread of human viruses (2008, background): “Many viruses that enter cells through pH-independent routes fuse their membranes directly with the cell plasma membrane, whereas viruses that require a pH change to penetrate the lipid membrane of the cell are first internalized by an endocytic mechanism, before fusing with an endosomal membran”
• Pathways of clathrin-independent endocytosis (2007, background): “Some of these pathways are constitutive, whereas others are triggered by specific signals or are even hijacked by pathogen”