Advances in protein kinase B signalling: AKTion on multiple fronts.

By D. Brazil, Zhong-Zhou Yang, B. Hemmings. TIBS -Trends in Biochemical Sciences. Regular ed, 2004

894 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/85c03a17d1a5a4ee7691b94301643d26ac47e5fa

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Citations in the corpus

Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial–mesenchymal transition (2005, background): “Akt kinases control these activities by phosphorylation-mediated regulation of multiple substrates (for reviews see Brazil et al., 2004; Woodgett, 2005).”
Mitochondrial mutations in cancer (2006, background): “The Akt kinases, in turn, mediate the signals of a variety of oncogenes (Aoki et al., 1998; Testa and Bellacosa, 2001; Brazil et al., 2004; Yanagihara et al., 2005).”
Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis (2010, background): “The regulation of Akt is extremely complex, involving multiple phosphorylation sites and multiple interacting proteins (37).”
Critical nodes in signalling pathways: insights into insulin action (2006, background): “AKT/PKB activity is regulated by several inhibitory molecules, including enzymes like the protein phosphatase-2A (PP2A) and the PH-domain leucine-rich repeat protein phosphatase (PHLPP), which directly dephosphorylate and deactivate AKT/PK”
Protein kinase cascades in the regulation of cardiac hypertrophy. (2005, background): “(also known as PKB) and its activator, 3-phosphoinositide–dependent protein kinase–1 (PDK1), to the cell membrane via interactions between kinase pleckstrin homology domains and the 3′-phosphorylated lipid (Figure 1) (20).”
Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions (2017, neutral): “For example, the AKT1_AKT2 and PIM1_PIM2 pairs are highly homologous kinase isoforms with known functional redundancy 36,37 and the BCL2L1_MCL1 and ATM_PRKDC pairs have similar biological functions (apoptosis and DNA damage repair, respectively).”
In brief (2011, positive): “For mSIN1, mNIP7, Rpl7, Rps16, PTEN, or Bad knockdown, a pool of four different synthetic siRNA or of the appropriate control siRNA (Dharmacon) was used as described (Thedieck et al., 2007).”
Perturbations of the AKT signaling pathway in human cancer (2005, background): “The biochemical mechanisms leading to AKT activation are well defined and have been recently reviewed in detail elsewhere (reviewed in Scheid and Woodgett, 2003; Brazil et al., 2004; Bellacosa et al., 2005).”