Autophagy promotes ferroptosis by degradation of ferritin

By W. Hou, Yangchun Xie, Xinxin Song, Xiaofang Sun, Michael Lotze, H. J. Zeh, R. Kang, D. Tang. Autophagy, 2016

2,020 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/a333281571305359dc5765d219c14d5a04d17f00

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Guido Kroemer
2. D. Tang
3. R. Kang
4. D. Klionsky
5. Craig B. Thompson
6. Brent R. Stockwell
7. Xin Chen
8. Jiao Liu

In Molecular Biology

1. Guido Kroemer
2. D. Tang
3. R. Kang
4. Xin Chen
5. Brent R. Stockwell
6. D. Klionsky
7. Jiao Liu
8. Tal Hirschhorn

In Pulmonary and Respiratory Medicine

1. D. Tang
2. R. Kang
3. Guido Kroemer
4. Brent R. Stockwell
5. Xin Chen
6. Tal Hirschhorn
7. Jiao Liu
8. Xuejun Jiang

Citations in the corpus

• The Development of the Concept of Ferroptosis (2018, positive): “degradation of iron storage proteins such as ferritin, which results in release of free iron [129,130].”
• Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications (2021, background): “Knockout or knockdown of autophagy‐related 5 (Atg5) and Atg7 limit erastin‐induced ferroptosis by decreasing intracellular ferrous iron levels and lipid peroxidation.(469) Therefore, ferroptosis may be a type of autophagy‐dependent cell death.”
• Autophagy-Dependent Ferroptosis: Machinery and Regulation (2020, background): “, resulting from the knockdown of SLC40A1/ferroportin) enhance the sensitivity to ferroptosis (Bogdan et al., 2016; Du et al., 2018; Gao et al., 2016; Geng et al., 2018; Hou et al., 2016; Yang and Stockwell, 2008).”
• Emerging mechanisms and disease relevance of ferroptosis (2020, background): “It has been demonstrated that ferritin-targeted autophagy, also known as ferritinophagy, results in the lysosomal degradation of ferritin and release of iron into the labile iron pool, thus causing increased sensitivity to ferroptosis [23,24].”
• Targeting cell death pathways for cancer therapy: recent developments in necroptosis, pyroptosis, ferroptosis, and cuproptosis research (2022, background): “Additionally, knockout or knockdown of the main genes governing autophagy reduces the effects of erastin on ferroptosis because intracellular ferrous iron levels are reduced [66].”
• Inhibition of neuronal ferroptosis protects hemorrhagic brain. (2017, background): “(56) found that autophagy promotes ferroptosis by degradation of ferritin in cancer cells.”
• Ferroptosis in cancer therapy: a novel approach to reversing drug resistance (2022, background): “Overexpression of nuclear receptor coactivator 4 increased intracellular LIP by increasing ferritin degradation (namely ferritinophagy) [21].”