Parkinson's disease: genetics and pathogenesis.

By J. Shulman, P. D. De Jager, M. Feany. Annual Review of Pathology, 2011

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Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences (2012, neutral): “…alterations, oxidative stress, and impaired clearance of misfolded proteins and damaged orga-* nelles by proteasomal and lysosomal degradation pathways contribute to the disease process (reviewed in Dawson et al , 2010; Corti et al , 2011; Martin et al , 2011; and Shulman et al , 2011).”
The Adverse Effects of Air Pollution on the Nervous System (2012, background): “Although different neurodegenerative diseases have distinct pathologies and clinical presentations, they often share common mechanisms such as protein aggregation, oxidative stress injury, neuroinflammation, microglial activation, apoptosis, and mitochondrial dysfunction, which ultimately result in ”
Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment (2012, background): “INTRODUCTION Parkinson’s disease (PD) is a common neurodegenerative disorder characterized by both motor and non-motor symptoms [1].”