Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia.

By Anne-Sophie Marsin, L. Bertrand, M. Rider, J. Deprez, Christophe Beauloye, M. Vincent, G. Berghe, David Carling, L. Hue. Current Biology, 2000

873 citations recorded by the source corpus.

Subfields: Cancer Research, Endocrinology, Diabetes and Metabolism, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/856d144a021a6eb2c68b0871db4d7805a6a11f9f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

In Endocrinology, Diabetes and Metabolism

In Molecular Biology

Citations in the corpus

AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function. (2011, background): “…and activation of two of four isoforms of 6-phosphofructo-2kinase, which synthesizes the glycolytic activator fructose-2,6-bisphosphate) (Marsin et al. 2000, 2002), fatty acid uptake (via translocation of the fatty acid transporter FAT/CD36) (Bonen et al. 2007), and fatty acid oxidation…”
The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis (2011, background): “AMPK activity promotes glycolysis by phosphorylation of PFK2 and negatively regulates protein synthesis by phos- phorylating the TSC1/TSC2 complex upstream of mTOR (Marsin et al, 2000; Gwinn et al, 2008).”
The Randle cycle revisited: a new head for an old hat. (2009, background): “This is the case for acetyl-CoA carboxylase (ACC)2 (48), heart PFK-2 (110), and Akt substrate 160, a Rab GTPase-activating protein that controls GLUT4 recruitment to the plasma membrane (174).”
AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury. (2004, background): “In particular, AMPK is also known to phosphorylate and activate PFK-2 during ischemia (6).”
Metformin Induces a Dietary Restriction–Like State and the Oxidative Stress Response to Extend C. elegans Healthspan via AMPK, LKB1, and SKN-1 (2010, background): “elegans proteins orthologous to mammalian metformin targets like glycogen synthase (which is inhibited in mammals by AMPK [81,82]), TOR kinase complex TORC2 (inhibited by AMPK from promoting gluconeogenesis by inducing PEPCK and glucose-6phosphatase transcription [83]), PFK-2/FBPase-2 (a target of A”
AMP‐activated protein kinase – development of the energy sensor concept (2006, background): “Other metabolic stresses that activate AMPK include ischaemia (Kudo et al. 1995) or hypoxia (Marsin et al. 2000), which have been shown to activate the kinase in heart muscle.”
Chapter 10 Metabolic and Molecular Responses of Fish to Hypoxia (2009, background): “…activity, GLUT-4 glucose transporter expression (Holmes et al., 1999), and translocation to the membrane (Kurth-Kraczek et al., 1999), and increased phosphofructokinase-2 (PFK-2) activity in rat cardiomyocytes (Marsin et al., 2000), all of which could enhance O2-independent ATP production.”
The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans. (2004, background): “For example, when energy availability is limited in rodents, AMPK functions to restore normal energy levels by stimulating glucose uptake in skeletal muscle and glycolysis in the heart and by promoting feeding by regulating a hypothalamic circuit (Marsin et al. 2000; Mu et al. 2001; Andersson et al.”
AMP‐activated protein kinase: the energy charge hypothesis revisited (2001, background): “" glycolysis (heart) 6-phosphofructo-2-kinase Ischaemia, oligomycin (26)”