Neurite branching on deformable substrates

By L. Flanagan, Yo-El Ju, B. Marg, M. Osterfield, P. Janmey. NeuroReport, 2002

791 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Cell Biology, Cellular and Molecular Neuroscience

View Paper: https://www.semanticscholar.org/paper/852b08b1c33ccd6156be10d48ff9b414572adbd2

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In Biomedical Engineering

In Cell Biology

In Cellular and Molecular Neuroscience

Citations in the corpus

Matrix elasticity directs stem cell lineage specification. (2006, background): “…Sweeney,1 and Dennis E. Discher1,2,3,4,* 1Pennsylvania Muscle Institute 2School of Engineering and Applied Science 3Cell & Molecular Biology Graduate Group 4Physics Graduate Group University of Pennsylvania, Philadelphia, PA 19104, USA *Contact: discher@seas.upenn.edu DOI 10.1016/j.cell.2006.06.044”
Fibroblast adaptation and stiffness matching to soft elastic substrates. (2007, background): “For example, fibroblasts achieve maximal spreading at substrate stiffness of ;10 kPa (6), whereas neurons branch more avidly on softer surfaces (,0.5 kPa) ( 13 ), and chondrocytes only begin to spread at 10 kPa (14).”
The effect of substrate stiffness on adult neural stem cell behavior. (2009, background): “The stiffness of the matrix has been recently shown to be important to both differentiated and undifferentiated cell types derived from the nervous system [13,16,19,20].”
Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion. (2005, background): “These cells extend processes that branch most effectively on soft surfaces with maximal branching on gels with stiffness of 50 Pa [Flanagan et al., 2002].”
Force Fluctuations within Focal Adhesions Mediate ECM-Rigidity Sensing to Guide Directed Cell Migration (2012, background): “, 2005), development of the nervous system (Flanagan et al., 2002; Koch et al., 2012), innate immunity (Mandeville et al.”
Substrate modulus directs neural stem cell behavior. (2008, background): “Recent work also indicated that peripheral nervous system cells (7, 8 ) and PC12 adrenal tumor cells (9,10) show variable neurite extension and branching on mechanically tunable matrices and culture substrates.”
New functions of Müller cells (2013, background): “4, right diagram) (Flanagan et al., 2002; Georges et al., 2006); neuronal growth cones are actively guided by soft substrates and avoid rigid substrates (Franze et al., 2009).”