Peroxynitrite reactions and formation in mitochondria.

By Rafael Radi, A. Cassina, R. Hodara, C. Quijano, L. Castro. Free Radical Biology & Medicine, 2002

623 citations recorded by the source corpus.

Subfields: Molecular Biology, Nutrition and Dietetics, Physiology

View Paper: https://www.semanticscholar.org/paper/8506fbf1cf2e308942b993f53d6ba94215beedcc

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Rafael Radi
2. P. Chan
3. G. Ferrer-Sueta
4. Víctor M. Víctor
5. A. Navarro
6. Qingzheng Kang
7. Chunxue Yang
8. P. Venditti

In Nutrition and Dietetics

1. Rafael Radi
2. J. Turrens
3. S. Dikalov

In Physiology

1. Rafael Radi
2. G. Ferrer-Sueta
3. Qingzheng Kang
4. Chunxue Yang
5. J. Turrens
6. S. Dikalov
7. K. Griendling
8. David I. Brown

Citations in the corpus

• Oxidative Stress and Diabetic Retinopathy (2007, background): “It can injure mitochondria leading to increase in mitochondrial pore opening and consequently apoptosis [104, 105].”
• Mitochondrial formation of reactive oxygen species (2003, background): “…This may, in turn, stimulate O2 _• formation (for example from Complex I; Poderoso et al. 1996), which in turn may react with more nitric oxide forming peroxynitrite, an oxidant capable of inhibiting important enzymes and affecting mitochondrial integrity (Cassina & Radi, 1996; Radi et al. 2002a).”
• Oxygen radicals, nitric oxide, and peroxynitrite: Redox pathways in molecular medicine (2018, background): “In fact, long incubation times of cells with •NO lead to inactivation of mitochondrial electron transport complexes I and II (110).”
• Oxidative stress and diabetic retinopathy: Molecular mechanisms, pathogenetic role and therapeutic implications (2020, background): “homeostasis and promoting the opening of the permeability transition pore, and consequently leads to cell apoptosis [164].”
• The physiology and pathophysiology of nitric oxide in the brain. (2005, background): “Protein nitration of MnSOD also triggers apoptosis due to the thiol oxidation- dependent assembly of the permeability transition pore (Radi et al., 2002).”
• Crosstalk between mitochondria and NADPH oxidases (2011, background): “peroxynitrite uncouples endothelial NO synthase (eNOS), switching from NO to O2 production, and increases production of mitochondrial ROS [23,24]; and H2O2 induces transformation of xanthine dehydrogenase into xanthine oxidase, a source of H2O2 and O2 [25].”
• Reactive oxygen species, heat stress and oxidative-induced mitochondrial damage. A review (2014, background): “The product, peroxynitrite (ONOO ), is also a very powerful oxidant [22,23].”
• Chemical biology of peroxynitrite: kinetics, diffusion, and radicals. (2009, background): “The biochemical mechanisms of peroxynitrite-mediated changes in cell and mitochondrial homeostasis and signaling of apoptotic and necrotic cell death have been reviewed elsewhere (9, 10).”
• The mitochondrial energy transduction system and the aging process. (2007, background): “Formation of the adduct decreases the steady-state level of ONOO from 30 nM to 2 nM (151) and is considered a detoxification pathway for mitochondrial ONOO that takes advantage of the high mitochondrial CO2 concentration (1 mM) (132).”
• Alcohol-induced oxidative stress. (2007, background): “Since NO can diffuse freely into the mitochondria, nitric oxide reacts rapidly with intramitochondrial superoxide (Radi et al., 2002).”