ErbB receptors and signaling pathways in cancer.

By N. Hynes, Gwen Macdonald. Current Opinion in Cell Biology, 2009

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Hallmarks of cancer: the next generation. (2011, positive): “The mitogenic signaling in cancer cells is, in contrast, better understood (Lemmon and Schlessinger, 2010; Witsch et al., 2010; Hynes and MacDonald, 2009; Perona, 2006).”
Pathological roles of MAPK signaling pathways in human diseases. (2010, background): “Mutations in the epidermal growth factor receptor (EGFR), which activates the ERK pathway, occur frequently in the lung and colorectal cancers [160,161].”
The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy (Review) (2017, positive): “Phosphoproteomics has a critical relevance for many aspects of biology and has a significant role for understanding the molecular mechanisms, especially those that lead to the genesis and growth of tumors (77-79).”
JMJD8 Promotes Malignant Progression of Lung Cancer by Maintaining EGFR Stability and EGFR/PI3K/AKT Pathway Activation (2021, background): “We revealed that JMJD8 plays a significant role in the proliferation, invasion and epithelial-mesenchymal transition of NSCLC cells by interacting with EGFR and enhancing its stability, which in turn promotes PI3K/AKT signaling.”