A role for local inflammation in the formation of drusen in the aging eye.

By Don H. Anderson, R. Mullins, G. Hageman, L. V. Johnson. American journal of ophthalmology-glaucoma, 2002

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An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice (2003, background): “Complement and IgG deposition in Ccl2 −/− and Ccr2 −/− mice Recent evidence suggests that complement activation and immune complex deposition occur in eyes of humans with AM”
Current concepts in the pathogenesis of age-related macular degeneration. (2004, background): “The role of chronic inflammation in AMD pathogenesis has led to the consideration of anti-inflammatory therapy as treatment for the early stages of the disease.(136,138) Better knowledge of the biological changes underlying AMD will also foster the development of sightrestoring treatments for the la”
Oxidative damage–induced inflammation initiates age-related macular degeneration (2008, background): “The presence of complement factor proteins in drusen in AMD eye”
Age‐related macular degeneration—emerging pathogenetic and therapeutic concepts (2006, methodology): “We have advanced a working model of AMD pathobiology based upon our studies (154,194) and the work of others (156,195).”
Understanding age-related macular degeneration (AMD): Relationships between the photoreceptor/retinal pigment epithelium/Bruch’s membrane/choriocapillaris complex (2012, background): “Other molecules that mediate local inflammation have also been identified in AMD tissue (Anderson et al., 2002).”