Oxidative damage–induced inflammation initiates age-related macular degeneration
By J. Hollyfield, V. Bonilha, M. Rayborn, Xiaoping Yang, K. Shadrach, Liang Lu, R. Ufret, R. G. Salomon, V. Perez. Nature Medicine, 2008
734 citations recorded by the source corpus.
Subfields: Ophthalmology, Radiology, Nuclear Medicine and Imaging
View Paper: https://www.semanticscholar.org/paper/c70fbc40eaa944755ecdb88081d053b948f9ace4
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Ophthalmology
Citations in the corpus
- Photoreceptor degeneration: genetic and mechanistic dissection of a complex trait (2010, positive): “CEP-adduct immunized mice have AMD-like features, which supports a role for these compounds in activation of the complement pathway in AM”
- The Role of the Reactive Oxygen Species and Oxidative Stress in the Pathomechanism of the Age-Related Ocular Diseases and Other Pathologies of the Anterior and Posterior Eye Segments in Adults (2016, background): “The oxidation of PUFAs leads to the development of peroxides and organic radicals [193], as well as other products such as carboxyethylpyrrole (CEP) and 4-hydroxy-2-nonenal (4-HNE), which form adducts with proteins and are accumulated in the outer retina and in drusen [194].”
- Horror autoinflammaticus: the molecular pathophysiology of autoinflammatory disease (*). (2009, background): “In mice, a very close approximation of the human disease can be generated by immunization with carboxyethylpyrrole, an oxidation fragment of docosahexaenoic acid that has been found attached to protein in the drusen and in the serum of people with AMD (age-related macular degeneration) (224).”
- Para-inflammation in the aging retina. (2009, background): “In an animal study, AMD-like changes were induced by immunizing the mice with carboxyethylpyrrole, a unique oxidation fragment of docosahexaenoid acid (Hollyfield et al., 2008).”
- Understanding age-related macular degeneration (AMD): Relationships between the photoreceptor/retinal pigment epithelium/Bruch’s membrane/choriocapillaris complex (2012, background): “When Hollyfield and colleagues injected CEP adducts into mice, AMD-like changes were observed in the mice (Hollyfield, 2010; Hollyfield et al., 2008; Hollyfield et al., 2010).”