SOX2, a Persistent Marker for Multipotential Neural Stem Cells Derived from Embryonic Stem Cells, the Embryo or the Adult

By P. Ellis, B. Fagan, S. Magness, Scott R. Hutton, O. Taranova, S. Hayashi, Andrew P. McMahon, M. Rao, L. Pevny. Developmental Neuroscience, 2004

771 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/846b4a55480c883f1dcf1209dd4be7a75be049cc

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Citations in the corpus

Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration (2011, background): “SOX2 is not restricted to pluripotent cells, as it is also the earliest definitive marker of the neural plat”
Sox2+ adult stem/progenitor cells are important for tissue regeneration and survival of mice (2011, positive): “Widespread Sox2 Expression in Adult Epithelial Tissues In order to systematically evaluate the expression patterns of Sox2 in adult tissues, we generated Sox2-GFP indicator mice from ESCs targeted with a previously characterized knockin construct (Ellis et al., 2004) (Figure 1A).”
In vivo fate analysis reveals the multipotent and self-renewal capacities of Sox2+ neural stem cells in the adult hippocampus. (2007, background): “In the same context, Sox2 has been implicated in NSCs (Bylund et al., 2003; Ellis et al., 2004; Ferri et al., 2004; Graham et al., 2003; Taranova et al., 2006), but the question of whether Sox2 + cells in the SGZ possess the multipotent and self-renewing capacities has remained unsolved.”
Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. (2010, background): “To provide independent conﬁrmation of inner cell-speciﬁc upregulation of Sox2 expression, we next analyzed mice that contained an EGFP reporter targeted to the Sox2 locus (Ellis et al., 2004).”
The Sox Family of Transcription Factors: Versatile Regulators of Stem and Progenitor Cell Fate (2013, positive): “Using Sox2-GFP knockin mice, Pevny and coworkers first demonstrated that Sox2 is not only expressed in fetal neural progenitors but also in proliferating cells in the adult CNS, specifically in neurogenic regions, such as the subventricular zone of the lateral ventricle and the subgranular zone of t”
Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse. (2008, methodology): “5 ES cells were targeted with a Sox2-GFP knockin construct described previously (Ellis et al., 2004).”
Epigenetic reprogramming and induced pluripotency (2009, background): “, 2007) and Sox2 (Ellis et al., 2004), and may require less epigenetic reprogramming than terminally differentiated cells.”
EphB signaling controls lineage plasticity of adult neural stem cell niche cells (2010, background): “Many genes associated with neural stem/progenitor cells, including nestin, Sox2, Prominin-1/CD133, and Notch-1, are commonly expressed in ependymal cells and subventricular zone astrocytes (Doetsch et al., 1997; Ellis et al., 2004; Ferri et al., 2004; Johansson et al., 1999; Sakakibara et al., 2002;”
Sox1 marks an activated neural stem/progenitor cell in the hippocampus (2012, background): “By contrast, SOX2 expression has been well characterized in adult neurogenic zones (Ellis et al., 2004; Ferri et al., 2004; Komitova and Eriksson, 2004; Brazel et al., 2005; Episkopou, 2005; Sottile et al., 2006; Suh et al., 2007).”