Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein.
By Xinli Lin, G. Koelsch, Shili Wu, D. Downs, A. Dashti, Jordan Tang. Proceedings of the National Academy of Sciences of the United States of America, 2000
772 citations recorded by the source corpus.
Subfields: Biotechnology, Molecular Biology, Physiology
View Paper: https://www.semanticscholar.org/paper/84552eac382cbd5086295f9b2ceb7d425fa0c3ae
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Citations in the corpus
- Trafficking and proteolytic processing of APP. (2012, background): “Expression cloning or biochemical purification led to the identification of a unique b-secretase enzyme (Sinha et al. 1999; Vassar et al. 1999; Yan et al. 1999; Hussain et al. 2000; Lin et al. 2000).”
- Transcriptional Regulation of BACE1, the β-Amyloid Precursor Protein β-Secretase, by Sp1 (2004, background): “BACE2 is a homolog of BACE (17, 28, 45) and cleaves APP at the -secretase site in vitro (17).”
- Alzheimer’s Disease and the β-Amyloid Peptide (2010, neutral): “strates outside of the bilayer [27–31].”