Functional profiling of the Saccharomyces cerevisiae genome

By G. Giaever, A. Chu, L. Ni, C. Connelly, L. Riles, S. Véronneau, Sally Dow, A. Lucau-Danila, K. Anderson, B. André and 63 more. Nature, 2002

4,402 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8434ec84b04f7d146d400fa5065bec093ed1fbbd

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Citations in the corpus

Nutritional Control of Growth and Development in Yeast (2012, background): “74 J. R. Broach D ow nloaded from https://academ ic.oup.com /genetics/article/192/1/73/5935009 by guest on 04 M arch 2022”
Why Do Hubs in the Yeast Protein Interaction Network Tend To Be Essential: Reexamining the Connection between the Network Topology and Essentiality (2008, methodology): “To confirm the centrality-lethality rule in the tested networks we used the results of a systematic gene deletion screen [ 25 ] in which 1,105 yeast genes were found to be essential for growth on rich glucose media.”
Quantitative phenotyping via deep barcode sequencing. (2009, methodology): “To complement the Bar-seq assay and to support its routine use, we assayed the commercially available version of the heterozygote yeast deletion collection pool (the ‘‘Invitrogen 6000’’ pool) (Giaever et al. 2002) by Bar-seq (see Supplemental Methods).”
The Chemical Genomic Portrait of Yeast: Uncovering a Phenotype for All Genes (2008, methodology): “We further tested the small set of 205 deletion strains that showed no Lethality (Giaever et al, 2002) Growth defect in rich medium (Deutschbauer et al., 2005) Growth defect in this study No phenotype in this study A 0 200 400 600 0 20 40 60 80 10 0 Experiments performed C um ul at iv e pe rc en t…”
Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe (2010, background): “1628" language="eng" relation="no"> Systematic genome-wide gene deletion collections of eukaryotic organisms provide powerful tools for investigating molecular mechanisms in basic biology and for identifying pathways that can be targeted in bioengineering or medical applications, as shown b”
Systematic Functional Annotation and Visualization of Biological Networks (2016, background): “In a chemical genomic screen, a genome-wide collection of yeast mutants is grown in the presence of a chemical compound and the relative fitness of each mutant is measured with respect to an untreated control (Giaever et al., 2002).”
Mistranslation-induced protein misfolding as a dominant constraint on coding-sequence evolution (2008, neutral): “Protein alignments were generated with MUSCLE 3.6 ( Edgar, 2004 ) and used to align gene sequences, except for fly where alignments were downloaded from the AAAWiki website.”