The Chemical Genomic Portrait of Yeast: Uncovering a Phenotype for All Genes

By Maureen Hillenmeyer, E. Fung, Jan Wildenhain, Sarah E. Pierce, Shawn Hoon, William Lee, M. Proctor, Robert P. St.Onge, Mike Tyers, Daphne Koller and 4 more. Science, 2008

1,015 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6e4cc84a8f5ed1df2479c27252bc3e5e9e70c53f

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In Molecular Biology

Citations in the corpus

Structure and dynamics of molecular networks: A novel paradigm of drug discovery: A comprehensive review (2012, background): “However, when knockouts were screened against a diverse small-molecule library and a wide range of environmental conditions, 97% of the gene-deletions demonstrated a fitness defect (Hillenmeyer et al., 2008).”
A genomic storm in critically injured humans (2011, background): “…processes and reduced effector T cell function are necessary to limit or localize the response to severe trauma, a prolonged or exaggerated period of immune suppression or defective immune response leads to increased susceptibility to secondary infections (Hotchkiss and Karl, 2003).”
A systematic survey identifies prions and illuminates sequence features of prionogenic proteins (2009, background): “Finally, we asked if the [SWI+] state might have beneficial consequences under some circumstances by subjecting cells to a condition previously shown to interact synthetically with mutations in SWI1 – exposure to the microtubule-inhibiting fungicide benomyl (Hillenmeyer et al., 2008).”
Integrative approaches for finding modular structure in biological networks (2013, background): “Molecular interactions can change dramatically in response to cellular cues, developmental stages, environmental stresses, pharmacological treatments and disease states 32,100,129,132,133 .”
High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities. (2015, neutral): “…to be an artifact of laboratory conditions—while some genes do indeed seem to be constitutively essential, many others revealed fitness defects only under environmental stress or in different genetic backgrounds (i.e., context-dependent essentiality) (Hillenmeyer et al., 2008; Ramani et al., 2012).”
Phenotypic Landscape of a Bacterial Cell (2010, neutral): “Fitness values are derived from measuring strain abundance in a test relative to control condition (Giaever et al., 2004; Girgis et al., 2009; Hillenmeyer et al., 2008; Hoon et al., 2008; Lee et al., 2005; Pan et al., 2004; Parsons et al., 2006; Warner et al., 2010; Xu et al., 2007).”
Translation of Genotype to Phenotype by a Hierarchy of Cell Subsystems (2016, background): “Second, some biological processes are likely not required for the phenotype tested— growth of cells in rich media—but instead may drive a wide variety of other phenotypes (Dowell et al., 2010; Hillenmeyer et al., 2008; Ideker and Krogan, 2012; Lee et al., 2014).”