Matrix Metalloproteinase-9 (MMP-9) as a Cancer Biomarker and MMP-9 Biosensors: Recent Advances

By Hao-Hsiu Huang. Italian National Conference on Sensors, 2018

654 citations recorded by the source corpus.

As one of the most widely investigated matrix metalloproteinases (MMPs), MMP-9 is a significant protease which plays vital roles in many biological processes. MMP-9 can cleave many extracellular matrix (ECM) proteins to regulate ECM remodeling. It can also cleave many plasma surface proteins to release them from the cell surface. MMP-9 has been widely found to relate to the pathology of cancers, including but not limited to invasion, metastasis and angiogenesis. Some recent research evaluated the value of MMP-9 as biomarkers to various specific cancers. Besides, recent research of MMP-9 biosensors discovered various novel MMP-9 biosensors to detect this enzyme. In this review, some recent advances in exploring MMP-9 as a biomarker in different cancers are summarized, and recent discoveries of novel MMP-9 biosensors are also presented.

Subfields: Cancer Research, Immunology and Allergy, Oncology

View Paper: https://www.semanticscholar.org/paper/6859dd8de1688b09b3c23b0c893c3b89bad9abc3

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In Cancer Research

1. Huanhuan Chen
2. Li-li Zheng
3. Zhenling Liu
4. Li-Ping Sun
5. Lei Shi

Citations in the corpus

• Angiogenic signaling pathways and anti-angiogenic therapy for cancer (2023, background): “The essential component type IV collagen and other matrix proteins are degraded by MMP-9, which induces basement membrane remodeling, triggers morphogenesis and sprouting of ECs to stimulate tumor angiogenesis.(326) The importance of MMP-2 is that the deletion of MMP-2 controls the angiogenesis and ”