Increased lipogenesis in cancer cells: new players, novel targets

By J. Swinnen, K. Brusselmans, G. Verhoeven. Current opinion in clinical nutrition and metabolic care, 2006

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Cellular Fatty Acid Metabolism and Cancer (2013, background): “Lipidmetabolism is also altered in rapidly proliferating cells (for general reviews, see Swinnen et al., 2006; DeBerardinis and Thompson, 2012; Santos and Schulze, 2012).”
Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical research. (2011, background): “[9] Swinnen JV, Brusselmans K, and Verhoeven G (2006).”
Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development (2013, background): “…tissues show aberrant activation of de novo lipogenesis and that inhibition of different enzymes within the FA biosynthesis pathway can block cancer cell growth (reviewed by Abramson, 2011; Igal, 2010; Menendez and Lupu, 2007; Santos and Schulze, 2012; Swinnen et al., 2006; Zaidi et al., 2012).”
Brick by brick: metabolism and tumor cell growth. (2008, background): “How do tumor cells synthesize fatty acids and lipids? It has been more than 50 years since the first demonstration that tumors synthesize fatty acids from glucose (Figure 3), and subsequent studies have proven that interrupting fatty acid synthesis can be used as a chemotherapeutic strategy [27].”
Fatty acid uptake and lipid storage induced by HIF-1α contribute to cell growth and survival after hypoxia-reoxygenation. (2014, background): “FAs can be obtained from the diet or synthesized de novo (Swinnen et al., 2006).”