Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple.

By Freya Q. Schafer, G. Buettner. Free Radical Biology & Medicine, 2001

4,441 citations recorded by the source corpus.

Subfields: Biophysics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/83e6053a171b8e5644d67785f43cac6a5a0cd92e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biophysics

1. Jian Jian Li
2. T. Kellős
3. G. Szalai
4. Douglas C. Wallace
5. Vincent Procaccio
6. E. Azzam
7. L. Liaudet
8. G. Galiba

In Molecular Biology

1. Christine H. Foyer
2. Douglas C. Wallace
3. Vincent Procaccio
4. W. Fan
5. E. Blumwald
6. M. Circu
7. T. Aw
8. M. Valko

Citations in the corpus

• Effects of exogenous hydrogen sulfide on the ascorbate and glutathione metabolism in wheat seedlings leaves under water stress (2011, background): “Ascorbate and glutathione are two crucial nonenzymatic compounds involved in defence against oxidative stress (Smirnoff 1996; Schafer and Buettner 2001).”
• Glutathione: new roles in redox signaling for an old antioxidant (2014, background): “Thus, changes in the GSH/GSSG ratio are fundamental in the fine-tuning of signal transduction, even under mild oxidative stress that underlies physiological events such as cell cycle regulation and other cellular processes (Schafer and Buettner, 2001).”
• Increasing the utilisation of sorghum, millets and pseudocereals: Developments in the science of their phenolic phytochemicals, biofortification and protein functionality (2014, background): “Oxidative stress-mediated conditions such as cardiovascular disease (Fearon and Faux, 2009) are also accompanied by loss of endogenous antioxidant compounds such as glutathione or decrease in glutathione-to-glutathione disulphide ratio (Schafer and Buettner, 2001).”
• An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations. (2007, background): “In particular, redox status is considered an important parameter for assessing the prooxidant environment in an in vivo system (213, 234).”
• The changing faces of glutathione, a cellular protagonist. (2003, background): “Glutathione is produced by almost all cell types and are present in two forms, reduced (rGSH) and oxidized (GSSG). rGSH is synthesized by two different mechanisms.”
• Oxidative Stress and Lipid Peroxidation Products in Cancer Progression and Therapy (2012, background): “A moderate increase in ROS can promote cell proliferation and differentiation [30, 31], whereas excessive amounts of ROS can cause oxidative damage.”
• Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury (2011, background): “Homeostatic cellular functions therefore require tight control of the redox environment [2; 99].”