Mechanisms of enhancement of human motor cortex excitability induced by interventional paired associative stimulation

By K. Stefan, E. Kunesch, R. Benecke, Leonardo G. Cohen, J. Classen. Journal of Physiology, 2002

647 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/83a545e1b8620cc1711bfd2b39767b534813333b

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In Cellular and Molecular Neuroscience

In Cognitive Neuroscience

In Neurology

Citations in the corpus

Non-invasive electrical and magnetic stimulation of the brain, spinal cord, roots and peripheral nerves: Basic principles and procedures for routine clinical and research application. An updated report from an I.F.C.N. Committee (2015, methodology): “LTP-like effects of PAS25 were also not associated with enhanced intracortical glutamatergic transmission as revealed by lack of ICF changes (Quartarone et al., 2006).”
Spike timing-dependent plasticity: from synapse to perception. (2006, background): “Remarkably, plasticity resembling STDP has been demonstrated in the human motor cortex (101, 114).”
A temporally asymmetric Hebbian rule governing plasticity in the human motor cortex. (2003, background): “Previous studies (Stefan et al. 2000; Stefan et al. 2002) had shown that this stimulation intensity evokes a mean MEP amplitude of the resting APB muscle averaging to approximately 1 mV in the resting APB.”
Effects of non-invasive cortical stimulation on skilled motor function in chronic stroke. (2005, background): “…function appear to rely to some extent on increased efficacy of NMDA receptor activity (Liebetanz et al., 2002; Nitsche et al., 2004a, b), a mechanism that also influences recruitment curves and intra- cortical inhibition (Ziemann et al., 1998a; Schwenkreis et al., 1999; Stefan et al., 2002).”
Determinants of the induction of cortical plasticity by non‐invasive brain stimulation in healthy subjects (2010, methodology): “…↑ utilitatian responses Pharmacological influences Wolters et al. (2003) PAS10 ms 90 pulse pairs at 0.05 Hz; TMS SI: 130% RMT ↓ in LTD-like plasticity in the presence of dextromethorphan Stefan et al. (2002) PAS25 ms 90 pulse pairs at 0.05 Hz; TMS SI: SI1mV ↓ in LTP-like plasticity in the presence…”
Therapeutic effects of non-invasive brain stimulation with direct currents (tDCS) in neuropsychiatric diseases (2014, positive): “The resulting plasticity involves glutamatergic 96 synapses, and is calcium-dependent (Nitsche et al., 2003a, 2004b; 97 Stefan et al., 2002; Wolters et al., 2003).”
Is there a future for therapeutic use of transcranial magnetic stimulation? (2007, background): “Like LTP/LTD, there is evidence from pharmacological interventions in humans that the after-effects of rTMS depend on the glutamatergic NMDA ( N -methyl- D -aspartate) receptor, as they are blocked by a single dose of the NMDA-receptor antagonist dextromethorpha”
Differential Modulation of Motor Cortical Plasticity and Excitability in Early and Late Phases of Human Motor Learning (2007, background): “The former has been shown previously to induce a long-lasting MEP increase (Stefan et al., 2000, 2002) and the latter an MEP decrease (Wolters et al., 2003).”